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Gene: FEN1 (flap structure-specific endonuclease 1) Homo sapiens
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Symbol: FEN1
Name: flap structure-specific endonuclease 1
Description: Exhibits DNA binding activity and nuclease activity. Involved in DNA replication, removal of RNA primer; nucleic acid phosphodiester bond hydrolysis; and positive regulation of sister chromatid cohesion. Localizes to the mitochondrion; nuclear lumen; and protein-containing complex. Colocalizes with the nuclear chromosome, telomeric region. Biomarker of breast cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: DNase IV; FEN-1; flap endonuclease 1; hFEN-1; maturation factor 1; maturation factor-1; MF1; RAD2
Orthologs:
Mus musculus (house mouse) : Fen1 (flap structure specific endonuclease 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Fen1 (flap structure-specific endonuclease 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Fen1 (flap structure-specific endonuclease 1)
Pan paniscus (bonobo/pygmy chimpanzee) : FEN1 (flap structure-specific endonuclease 1)
Canis lupus familiaris (dog) : FEN1 (flap structure-specific endonuclease 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Fen1 (flap structure-specific endonuclease 1)
Sus scrofa (pig) : FEN1 (flap structure-specific endonuclease 1)
more info ...
Related Pseudogenes: FEN1P1  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381161,792,911 - 61,797,238 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371161,560,109 - 61,564,716 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361161,316,726 - 61,321,286 (+)NCBINCBI36hg18NCBI36
Build 341161,316,725 - 61,321,284NCBI
Celera1158,895,562 - 58,900,122 (+)NCBI
Cytogenetic Map11q12.2NCBI
HuRef1157,888,343 - 57,892,951 (+)NCBIHuRef
CHM1_11161,443,324 - 61,447,931 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on FEN1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732679
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.