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Gene: Mmp12 (matrix metallopeptidase 12) Mus musculus
Symbol: Mmp12
Name: matrix metallopeptidase 12
Description: Predicted to have several functions, including DNA binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in several processes, including positive regulation of interferon-alpha secretion; regulation of gene expression; and regulation of type I interferon-mediated signaling pathway. Localizes to extracellular space and nucleus. Human ortholog(s) of this gene implicated in Barrett's esophagus; artery disease (multiple); coronary aneurysm; esophagus adenocarcinoma; and multiple sclerosis. Is expressed in gonad; mesonephros; and testis. Orthologous to human MMP12 (matrix metallopeptidase 12).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AV378681; macrophage elastase; macrophage metalloelastase; macrophage-metalloelastase; matrix metalloproteinase 12; matrix metalloproteinase-12; MME; Mmel; MMP-12
Homo sapiens (human) : MMP12 (matrix metallopeptidase 12)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mmp12 (matrix metallopeptidase 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp12 (matrix metallopeptidase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP12 (matrix metallopeptidase 12)
Canis lupus familiaris (dog) : MMP12 (matrix metallopeptidase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp12 (matrix metallopeptidase 12)
Sus scrofa (pig) : MMP12 (matrix metallopeptidase 12)
Chlorocebus sabaeus (African green monkey) : MMP12 (matrix metallopeptidase 12)
Heterocephalus glaber (naked mole-rat) : Mmp12 (matrix metallopeptidase 12)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl97,344,381 - 7,369,499 (+)EnsemblGRCm38mm10GRCm38
GRCm3897,344,397 - 7,360,461 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3797,347,374 - 7,360,461 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,347,406 - 7,360,461 (+)NCBImm8
Celera94,747,651 - 4,760,738 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Mmp12
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732694
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.