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Gene: Mmp12 (matrix metallopeptidase 12) Mus musculus
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Symbol: Mmp12
Name: matrix metallopeptidase 12
Description: Predicted to have several functions, including DNA binding activity; metal ion binding activity; and metalloendopeptidase activity. Involved in several processes, including positive regulation of interferon-alpha secretion; regulation of gene expression; and regulation of type I interferon-mediated signaling pathway. Localizes to extracellular space and nucleus. Human ortholog(s) of this gene implicated in Barrett's esophagus; artery disease (multiple); coronary aneurysm; esophagus adenocarcinoma; and multiple sclerosis. Is expressed in gonad; mesonephros; and testis. Orthologous to human MMP12 (matrix metallopeptidase 12).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AV378681; macrophage elastase; macrophage metalloelastase; macrophage-metalloelastase; matrix metalloproteinase 12; matrix metalloproteinase-12; MME; Mmel; MMP-12
Orthologs:
Homo sapiens (human) : MMP12 (matrix metallopeptidase 12)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Mmp12 (matrix metallopeptidase 12)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Mmp12 (matrix metallopeptidase 12)
Pan paniscus (bonobo/pygmy chimpanzee) : MMP12 (matrix metallopeptidase 12)
Canis lupus familiaris (dog) : MMP12 (matrix metallopeptidase 12)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Mmp12 (matrix metallopeptidase 12)
Sus scrofa (pig) : MMP12 (matrix metallopeptidase 12)
Chlorocebus sabaeus (African green monkey) : MMP12 (matrix metallopeptidase 12)
Heterocephalus glaber (naked mole-rat) : Mmp12 (matrix metallopeptidase 12)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl97,344,381 - 7,369,499 (+)EnsemblGRCm38mm10GRCm38
GRCm3897,344,397 - 7,360,461 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3797,347,374 - 7,360,461 (+)NCBIGRCm37mm9NCBIm37
MGSCv3697,347,406 - 7,360,461 (+)NCBImm8
Celera94,747,651 - 4,760,738 (+)NCBICelera
Cytogenetic Map9A1NCBI
cM Map92.46NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Mmp12
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732694
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.