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Gene: Nbn (nibrin) Mus musculus
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Symbol: Nbn
Name: nibrin
Description: Exhibits damaged DNA binding activity. Predicted to contribute to DNA helicase activity. Involved in several processes, including blastocyst growth; isotype switching; and mitotic G2 DNA damage checkpoint. Localizes to the PML body; nuclear chromosome, telomeric region; and replication fork. Used to study Nijmegen breakage syndrome. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; aplastic anemia; breast cancer; precursor lymphoblastic lymphoma/leukemia; and reproductive organ cancer (multiple). Is expressed in genitourinary system and pituitary gland. Orthologous to human NBN (nibrin); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell cycle regulatory protein p95; Nbs1; nijmegen breakage syndrome protein 1 homolog
Orthologs:
Homo sapiens (human) : NBN (nibrin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nbn (nibrin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nbn (nibrin)
Pan paniscus (bonobo/pygmy chimpanzee) : NBN (nibrin)
Canis lupus familiaris (dog) : NBN (nibrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nbn (nibrin)
Sus scrofa (pig) : NBN (nibrin)
Chlorocebus sabaeus (African green monkey) : NBN (nibrin)
Heterocephalus glaber (naked mole-rat) : Nbn (nibrin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl415,957,925 - 15,992,589 (+)Ensembl
GRCm38415,957,587 - 15,992,589 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37415,885,114 - 15,919,736 (+)NCBIGRCm37mm9NCBIm37
MGSCv36415,885,115 - 15,919,736 (+)NCBImm8
Celera415,761,229 - 15,795,887 (+)NCBICelera
Cytogenetic Map4 A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nbn
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732723
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.