Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Nbn (nibrin) Mus musculus
Symbol: Nbn
Name: nibrin
Description: Exhibits damaged DNA binding activity. Predicted to contribute to DNA helicase activity. Involved in several processes, including blastocyst growth; isotype switching; and mitotic G2 DNA damage checkpoint. Localizes to the PML body; nuclear chromosome, telomeric region; and replication fork. Used to study Nijmegen breakage syndrome. Human ortholog(s) of this gene implicated in several diseases, including Nijmegen breakage syndrome; aplastic anemia; breast cancer; precursor lymphoblastic lymphoma/leukemia; and reproductive organ cancer (multiple). Is expressed in genitourinary system and pituitary gland. Orthologous to human NBN (nibrin); PARTICIPATES IN ataxia telangiectasia-mutated (ATM) signaling pathway; homologous recombination pathway of double-strand break repair; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 4-hydroxynon-2-enal.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: cell cycle regulatory protein p95; Nbs1; nijmegen breakage syndrome protein 1 homolog
Homo sapiens (human) : NBN (nibrin)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nbn (nibrin)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nbn (nibrin)
Pan paniscus (bonobo/pygmy chimpanzee) : NBN (nibrin)
Canis lupus familiaris (dog) : NBN (nibrin)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nbn (nibrin)
Sus scrofa (pig) : NBN (nibrin)
Chlorocebus sabaeus (African green monkey) : NBN (nibrin)
Heterocephalus glaber (naked mole-rat) : Nbn (nibrin)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl415,957,925 - 15,992,589 (+)Ensembl
GRCm38415,957,587 - 15,992,589 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37415,885,114 - 15,919,736 (+)NCBIGRCm37mm9NCBIm37
MGSCv36415,885,115 - 15,919,736 (+)NCBImm8
Celera415,761,229 - 15,795,887 (+)NCBICelera
Cytogenetic Map4 A2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Nbn
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732723
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-11-27
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.