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Gene: ARNT (aryl hydrocarbon receptor nuclear translocator) Homo sapiens
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Symbol: ARNT
Name: aryl hydrocarbon receptor nuclear translocator
Description: Exhibits DNA binding activity; aryl hydrocarbon receptor binding activity; and protein dimerization activity. Contributes to DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific DNA binding activity. Involved in positive regulation of vascular endothelial growth factor production; regulation of cellular biosynthetic process; and response to hypoxia. Localizes to the RNA polymerase II transcription factor complex and nuclear body. Implicated in renal cell carcinoma. Biomarker of type 2 diabetes mellitus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: bHLHe2; class E basic helix-loop-helix protein 2; dioxin receptor, nuclear translocator; HIF-1-beta; HIF-1beta; HIF1-beta; HIF1B; HIF1BETA; hypoxia-inducible factor 1, beta subunit; hypoxia-inducible factor 1-beta; TANGO
Orthologs:
Mus musculus (house mouse) : Arnt (aryl hydrocarbon receptor nuclear translocator)  MGI  Alliance
Rattus norvegicus (Norway rat) : Arnt (aryl hydrocarbon receptor nuclear translocator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Arnt (aryl hydrocarbon receptor nuclear translocator)
Pan paniscus (bonobo/pygmy chimpanzee) : ARNT (aryl hydrocarbon receptor nuclear translocator)
Canis lupus familiaris (dog) : ARNT (aryl hydrocarbon receptor nuclear translocator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Arnt (aryl hydrocarbon receptor nuclear translocator)
Sus scrofa (pig) : ARNT (aryl hydrocarbon receptor nuclear translocator)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381150,809,713 - 150,876,737 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371150,782,181 - 150,849,244 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361149,048,810 - 149,115,810 (-)NCBINCBI36hg18NCBI36
Build 341147,595,258 - 147,662,259NCBI
Celera1123,898,224 - 123,964,878 (-)NCBI
Cytogenetic Map1q21.3NCBI
HuRef1122,159,809 - 122,226,754 (-)NCBIHuRef
CHM1_11152,177,524 - 152,244,584 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ARNT
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732739
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.