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Gene: NR4A1 (nuclear receptor subfamily 4 group A member 1) Homo sapiens
Symbol: NR4A1
Name: nuclear receptor subfamily 4 group A member 1
Description: Predicted to have several functions, including DNA-binding transcription activator activity, RNA polymerase II-specific; glucocorticoid receptor binding activity; and protein heterodimerization activity. Involved in several processes, including cellular response to growth factor stimulus; endothelial cell migration; and positive regulation of endothelial cell proliferation. Localizes to the cytosol; nuclear membrane; and nucleoplasm.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: early response protein NAK1; GFRP1; growth factor-inducible nuclear protein N10; HMR; hormone receptor; immediate early gene transcription factor ngfi-b; MGC9485; N10; NAK-1; nerve growth factor IB nuclear receptor variant 1; NGFIB; NP10; nuclear hormone receptor NUR/77; nuclear receptor subfamily 4, group A, member 1; NUR77; orphan nuclear receptor HMR; orphan nuclear receptor TR3; ST-59; steroid receptor TR3; testicular receptor 3; TR3; TR3 orphan receptor
Mus musculus (house mouse) : Nr4a1 (nuclear receptor subfamily 4, group A, member 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr4a1 (nuclear receptor subfamily 4, group A, member 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr4a1 (nuclear receptor subfamily 4 group A member 1)
Pan paniscus (bonobo/pygmy chimpanzee) : NR4A1 (nuclear receptor subfamily 4 group A member 1)
Canis lupus familiaris (dog) : NR4A1 (nuclear receptor subfamily 4 group A member 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr4a1 (nuclear receptor subfamily 4 group A member 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381252,022,832 - 52,059,507 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371252,416,616 - 52,453,291 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361250,731,458 - 50,739,554 (+)NCBINCBI36hg18NCBI36
Build 341250,723,762 - 50,736,019NCBI
Celera1251,247,867 - 51,255,961 (+)NCBI
Cytogenetic Map12q13.13NCBI
HuRef1249,449,770 - 49,486,519 (+)NCBIHuRef
CHM1_11252,382,884 - 52,419,560 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NR4A1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732751
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.