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Gene: PTK2 (protein tyrosine kinase 2) Homo sapiens
Symbol: PTK2
Name: protein tyrosine kinase 2
Description: Exhibits several functions, including SH2 domain binding activity; enzyme binding activity; and non-membrane spanning protein tyrosine kinase activity. Involved in several processes, including cell surface receptor signaling pathway; positive regulation of intracellular signal transduction; and protein phosphorylation. Localizes to several cellular components, including cytosol; focal adhesion; and stress fiber. Implicated in leiomyoma; lung small cell carcinoma; and pulmonary hypertension. Biomarker of ductal carcinoma in situ; endometrial hyperplasia; endometriosis (multiple); lung small cell carcinoma; and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FADK; FADK 1; FAK; FAK-related non-kinase polypeptide; FAK1; focal adhesion kinase 1; focal adhesion kinase isoform FAK-Del33; focal adhesion kinase-related nonkinase; FRNK; p125FAK; pp125FAK; PPP1R71; protein phosphatase 1 regulatory subunit 71; protein phosphatase 1, regulatory subunit 71; protein-tyrosine kinase 2; PTK2 protein tyrosine kinase 2
Mus musculus (house mouse) : Ptk2 (PTK2 protein tyrosine kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ptk2 (protein tyrosine kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ptk2 (protein tyrosine kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PTK2 (protein tyrosine kinase 2)
Canis lupus familiaris (dog) : PTK2 (protein tyrosine kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ptk2 (protein tyrosine kinase 2)
Sus scrofa (pig) : PTK2 (protein tyrosine kinase 2)
Chlorocebus sabaeus (African green monkey) : PTK2 (protein tyrosine kinase 2)
Heterocephalus glaber (naked mole-rat) : Ptk2 (protein tyrosine kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl8140,657,900 - 141,002,216 (-)EnsemblGRCh38hg38GRCh38
GRCh388140,657,900 - 141,002,079 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378141,668,481 - 142,011,412 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368141,737,683 - 142,080,514 (-)NCBINCBI36hg18NCBI36
Build 348141,737,682 - 142,080,514NCBI
Celera8137,836,859 - 138,179,410 (-)NCBI
Cytogenetic Map8q24.3NCBI
HuRef8136,979,065 - 137,322,195 (-)NCBIHuRef
CHM1_18141,708,729 - 142,051,666 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences