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Gene: KL (klotho) Homo sapiens
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Symbol: KL
Name: klotho
Description: Exhibits fibroblast growth factor binding activity. Involved in aging and positive regulation of bone mineralization. Localizes to the extracellular exosome. Implicated in Prinzmetal angina; coronary artery disease; intracranial embolism; and spondylosis. Biomarker of chronic kidney disease and end stage renal failure.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: HFTC3
Orthologs:
Mus musculus (house mouse) : Kl (klotho)  MGI  Alliance
Rattus norvegicus (Norway rat) : Kl (Klotho)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Kl (klotho)
Pan paniscus (bonobo/pygmy chimpanzee) : KL (klotho)
Canis lupus familiaris (dog) : KL (klotho)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Kl (klotho)
Sus scrofa (pig) : KL (klotho)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381333,016,063 - 33,066,143 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371333,590,571 - 33,640,282 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361332,488,571 - 32,538,279 (+)NCBINCBI36hg18NCBI36
Build 341332,488,570 - 32,538,279NCBI
Celera1314,657,386 - 14,707,106 (+)NCBI
Cytogenetic Map13q13.1NCBI
HuRef1314,401,659 - 14,452,070 (+)NCBIHuRef
CHM1_11333,558,119 - 33,607,832 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on KL
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732783
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.