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Gene: LMNA (lamin A/C) Homo sapiens
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Symbol: LMNA
Name: lamin A/C
Description: Exhibits identical protein binding activity. Involved in several processes, including cellular response to hypoxia; positive regulation of cell aging; and regulation of telomere maintenance. Localizes to the cytosol; nucleus; and perinuclear region of cytoplasm. Implicated in several diseases, including Charcot-Marie-Tooth disease type 2B1; intrinsic cardiomyopathy (multiple); lipodystrophy (multiple); muscular dystrophy (multiple); and type 2 diabetes mellitus (multiple). Biomarker of aortic valve disease 2.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 70 kDa lamin; cardiomyopathy, dilated 1A (autosomal dominant); CDCD1; CDDC; CMD1A; CMT2B1; EMD2; FPL; FPLD; FPLD2; HGPS; IDC; lamin; lamin a; lamin A/C-like 1; lamin-A/C; LDP1; LFP; LGMD1B; LMN1; LMNC; LMNL1; MADA; mandibuloacral dysplasia type A; prelamin-A/C; PRO1; progeria 1 (Hutchinson-Gilford type); renal carcinoma antigen NY-REN-32
Orthologs:
Mus musculus (house mouse) : Lmna (lamin A)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lmna (lamin A/C)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lmna (lamin A/C)
Pan paniscus (bonobo/pygmy chimpanzee) : LMNA (lamin A/C)
Canis lupus familiaris (dog) : LMNA (lamin A/C)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lmna (lamin A/C)
Sus scrofa (pig) : LMNA (lamin A/C)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381156,082,546 - 156,140,089 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371156,052,369 - 156,109,880 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361154,351,085 - 154,376,502 (+)NCBINCBI36hg18NCBI36
Build 341152,897,570 - 152,922,944NCBI
Celera1129,157,453 - 129,182,870 (+)NCBI
Cytogenetic Map1q22NCBI
HuRef1127,414,589 - 127,472,062 (+)NCBIHuRef
CHM1_11157,448,449 - 157,505,990 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model