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Gene: PAK2 (p21 (RAC1) activated kinase 2) Homo sapiens
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Symbol: PAK2
Name: p21 (RAC1) activated kinase 2
Description: Exhibits several functions, including enzyme binding activity; identical protein binding activity; and protein tyrosine kinase activator activity. Involved in several processes, including bicellular tight junction assembly; protein phosphorylation; and regulation of apoptotic process. Localizes to the cell-cell junction and cytosol. Implicated in ductal carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: gamma-PAK; p21 (CDKN1A)-activated kinase 2; p21 protein (Cdc42/Rac)-activated kinase 2; p21-activated kinase 2; p58; PAK-2; PAK65; PAKgamma; S6/H4 kinase; serine/threonine-protein kinase PAK 2
Orthologs:
Mus musculus (house mouse) : Pak2 (p21 (RAC1) activated kinase 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pak2 (p21 (RAC1) activated kinase 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pak2 (p21 (RAC1) activated kinase 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PAK2 (p21 (RAC1) activated kinase 2)
Canis lupus familiaris (dog) : PAK2 (p21 (RAC1) activated kinase 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pak2 (p21 (RAC1) activated kinase 2)
Sus scrofa (pig) : PAK2 (p21 (RAC1) activated kinase 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,739,857 - 196,832,647 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh373196,466,728 - 196,559,518 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,951,312 - 198,043,756 (+)NCBINCBI36hg18NCBI36
Build 343197,955,224 - 198,047,662NCBI
Celera3195,047,767 - 195,144,272 (+)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,763,319 - 193,859,670 (+)NCBIHuRef
CHM1_13196,437,954 - 196,530,860 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PAK2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732793
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.