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Gene: IDE (insulin degrading enzyme) Homo sapiens
Symbol: IDE
Name: insulin degrading enzyme
Description: Exhibits several functions, including ATP binding activity; insulin binding activity; and protein homodimerization activity. Involved in several processes, including amyloid-beta clearance by cellular catabolic process; peptide metabolic process; and protein catabolic process. Localizes to several cellular components, including the basolateral plasma membrane; external side of plasma membrane; and peroxisome. Implicated in type 2 diabetes mellitus. Biomarker of Alzheimer's disease and diabetic encephalopathy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Abeta-degrading protease; FLJ35968; insulin protease; insulin-degrading enzyme; insulinase; insulysin
Mus musculus (house mouse) : Ide (insulin degrading enzyme)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ide (insulin degrading enzyme)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ide (insulin degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : IDE (insulin degrading enzyme)
Canis lupus familiaris (dog) : IDE (insulin degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ide (insulin degrading enzyme)
Sus scrofa (pig) : IDE (insulin degrading enzyme)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh381092,451,684 - 92,574,095 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371094,211,441 - 94,333,852 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361094,203,580 - 94,323,832 (-)NCBINCBI36hg18NCBI36
Build 341094,204,018 - 94,323,813NCBI
Celera1087,952,861 - 88,075,347 (-)NCBI
Cytogenetic Map10q23.33NCBI
HuRef1087,837,258 - 87,960,004 (-)NCBIHuRef
CHM1_11094,493,176 - 94,615,858 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on IDE
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732801
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.