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Gene: Ide (insulin degrading enzyme) Mus musculus
Symbol: Ide
Name: insulin degrading enzyme
Description: Predicted to have several functions, including ATP binding activity; peptide binding activity; and protein homodimerization activity. Involved in amyloid-beta clearance and insulin catabolic process. Localizes to extracellular exosome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human IDE (insulin degrading enzyme); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300012G03Rik; 4833415K22Rik; AA675336; AI507533; insulin protease; insulin-degrading enzyme; insulinase; insulysin
Homo sapiens (human) : IDE (insulin degrading enzyme)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ide (insulin degrading enzyme)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ide (insulin degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : IDE (insulin degrading enzyme)
Canis lupus familiaris (dog) : IDE (insulin degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ide (insulin degrading enzyme)
Sus scrofa (pig) : IDE (insulin degrading enzyme)
Chlorocebus sabaeus (African green monkey) : IDE (insulin degrading enzyme)
Heterocephalus glaber (naked mole-rat) : Ide (insulin degrading enzyme)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Annotation category: partial on reference assembly
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
GRCm381937,268,741 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBImm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Ide
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732802
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.