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Gene: Ide (insulin degrading enzyme) Mus musculus
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Symbol: Ide
Name: insulin degrading enzyme
Description: Predicted to have several functions, including ATP binding activity; peptide binding activity; and protein homodimerization activity. Involved in amyloid-beta clearance and insulin catabolic process. Localizes to extracellular exosome. Human ortholog(s) of this gene implicated in Alzheimer's disease and type 2 diabetes mellitus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Orthologous to human IDE (insulin degrading enzyme); PARTICIPATES IN Alzheimer's disease pathway; INTERACTS WITH 17alpha-ethynylestradiol; 2,3,7,8-tetrachlorodibenzodioxine; 3,4-methylenedioxymethamphetamine.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 1300012G03Rik; 4833415K22Rik; AA675336; AI507533; insulin protease; insulin-degrading enzyme; insulinase; insulysin
Orthologs:
Homo sapiens (human) : IDE (insulin degrading enzyme)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Ide (insulin degrading enzyme)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ide (insulin degrading enzyme)
Pan paniscus (bonobo/pygmy chimpanzee) : IDE (insulin degrading enzyme)
Canis lupus familiaris (dog) : IDE (insulin degrading enzyme)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ide (insulin degrading enzyme)
Sus scrofa (pig) : IDE (insulin degrading enzyme)
Chlorocebus sabaeus (African green monkey) : IDE (insulin degrading enzyme)
Heterocephalus glaber (naked mole-rat) : Ide (insulin degrading enzyme)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
NCBI Annotation Information: Annotation category: partial on reference assembly
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl1937,268,743 - 37,337,852 (-)EnsemblGRCm38mm10GRCm38
GRCm381937,268,741 - 37,334,544 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371937,343,231 - 37,409,034 (-)NCBIGRCm37mm9NCBIm37
MGSCv361937,335,574 - 37,399,688 (-)NCBImm8
Celera1938,043,942 - 38,138,431 (-)NCBICelera
Cytogenetic Map19C2NCBI
cM Map1932.24NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Ide
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732802
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.