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Gene: MAP2K6 (mitogen-activated protein kinase kinase 6) Homo sapiens
Symbol: MAP2K6
Name: mitogen-activated protein kinase kinase 6
CRRD ID: 732805
Description: Exhibits MAP kinase kinase activity; identical protein binding activity; and protein kinase binding activity. Involved in activation of MAPK activity. Localizes to cytosol and nucleoplasm. Implicated in Pick's disease; cervical cancer; ovarian carcinoma; progressive supranuclear palsy; and restrictive cardiomyopathy. Biomarker of prostate carcinoma in situ.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: dual specificity mitogen-activated protein kinase kinase 6; MAP kinase kinase 6; MAPK/ERK kinase 6; MAPKK 6; MAPKK6; MEK 6; MEK6; MKK6; PRKMK6; protein kinase, mitogen-activated, kinase 6 (MAP kinase kinase 6); SAPK kinase 3; SAPKK-3; SAPKK3; stress-activated protein kinase kinase 3
Mus musculus (house mouse) : Map2k6 (mitogen-activated protein kinase kinase 6)  MGI  Alliance
Rattus norvegicus (Norway rat) : Map2k6 (mitogen-activated protein kinase kinase 6)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Map2k6 (mitogen-activated protein kinase kinase 6)
Pan paniscus (bonobo/pygmy chimpanzee) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Canis lupus familiaris (dog) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Sus scrofa (pig) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Chlorocebus sabaeus (African green monkey) : MAP2K6 (mitogen-activated protein kinase kinase 6)
Heterocephalus glaber (naked mole-rat) : Map2k6 (mitogen-activated protein kinase kinase 6)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1769,414,697 - 69,553,865 (+)EnsemblGRCh38hg38GRCh38
GRCh381769,414,697 - 69,553,865 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371767,410,838 - 67,538,470 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361764,922,433 - 65,050,065 (+)NCBINCBI36hg18NCBI36
Build 341765,010,164 - 65,051,067NCBI
Celera1763,982,421 - 64,110,030 (+)NCBI
Cytogenetic Map17q24.3NCBI
HuRef1762,796,464 - 62,924,594 (+)NCBIHuRef
CHM1_11767,475,265 - 67,603,400 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on MAP2K6
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732805
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.