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Gene: SLC12A2 (solute carrier family 12 member 2) Homo sapiens
Symbol: SLC12A2
Name: solute carrier family 12 member 2
Description: Exhibits ammonium transmembrane transporter activity and protein kinase binding activity. Involved in several processes, including T cell chemotaxis; transepithelial ammonium transport; and transepithelial chloride transport. Localizes to the extracellular exosome. Biomarker of middle cerebral artery infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basolateral Na-K-Cl symporter; BSC; BSC2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; MGC104233; NKCC1; PPP1R141; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12, member 2
Mus musculus (house mouse) : Slc12a2 (solute carrier family 12, member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc12a2 (solute carrier family 12 member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a2 (solute carrier family 12 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A2 (solute carrier family 12 member 2)
Canis lupus familiaris (dog) : SLC12A2 (solute carrier family 12 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a2 (solute carrier family 12 member 2)
Sus scrofa (pig) : SLC12A2 (solute carrier family 12 member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385128,083,766 - 128,189,677 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375127,419,483 - 127,525,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365127,447,382 - 127,553,279 (+)NCBINCBI36hg18NCBI36
Build 345127,447,381 - 127,553,278NCBI
Celera5123,551,492 - 123,657,387 (+)NCBI
Cytogenetic Map5q23.3NCBI
HuRef5122,610,291 - 122,716,113 (+)NCBIHuRef
CHM1_15126,852,070 - 126,957,950 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLC12A2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732816
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.