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Gene: SLC12A2 (solute carrier family 12 member 2) Homo sapiens
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Symbol: SLC12A2
Name: solute carrier family 12 member 2
Description: Exhibits ammonium transmembrane transporter activity and protein kinase binding activity. Involved in several processes, including T cell chemotaxis; transepithelial ammonium transport; and transepithelial chloride transport. Localizes to the extracellular exosome. Biomarker of middle cerebral artery infarction.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: basolateral Na-K-Cl symporter; BSC; BSC2; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 1; bumetanide-sensitive sodium-(potassium)-chloride cotransporter 2; MGC104233; NKCC1; PPP1R141; solute carrier family 12 (sodium/potassium/chloride transporter), member 2; solute carrier family 12 (sodium/potassium/chloride transporters), member 2; solute carrier family 12, member 2
Orthologs:
Mus musculus (house mouse) : Slc12a2 (solute carrier family 12, member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc12a2 (solute carrier family 12 member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a2 (solute carrier family 12 member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A2 (solute carrier family 12 member 2)
Canis lupus familiaris (dog) : SLC12A2 (solute carrier family 12 member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a2 (solute carrier family 12 member 2)
Sus scrofa (pig) : SLC12A2 (solute carrier family 12 member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh385128,083,766 - 128,189,677 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375127,419,483 - 127,525,380 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365127,447,382 - 127,553,279 (+)NCBINCBI36hg18NCBI36
Build 345127,447,381 - 127,553,278NCBI
Celera5123,551,492 - 123,657,387 (+)NCBI
Cytogenetic Map5q23.3NCBI
HuRef5122,610,291 - 122,716,113 (+)NCBIHuRef
CHM1_15126,852,070 - 126,957,950 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC12A2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732816
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.