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Gene: Tnfsf10 (tumor necrosis factor (ligand) superfamily, member 10) Mus musculus
Symbol: Tnfsf10
Name: tumor necrosis factor (ligand) superfamily, member 10
Description: Exhibits TRAIL binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Predicted to localize to extracellular space; integral component of membrane; and plasma membrane. Is expressed in central nervous system; renal vasculature; and retina. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10); PARTICIPATES IN Trail mediated signaling pathway; apoptotic cell death pathway; influenza A pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A330042I21Rik; AI448571; APO-2L; Ly81; TL2; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand; Tnlg6a; Trail; TRAIL/APO2L; tumor necrosis factor ligand 6a; tumor necrosis factor ligand superfamily member 10
Homo sapiens (human) : TNFSF10 (TNF superfamily member 10)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tnfsf10 (TNF superfamily member 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfsf10 (TNF superfamily member 10)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFSF10 (TNF superfamily member 10)
Canis lupus familiaris (dog) : TNFSF10 (TNF superfamily member 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfsf10 (TNF superfamily member 10)
Sus scrofa (pig) : TNFSF10 (TNF superfamily member 10)
Chlorocebus sabaeus (African green monkey) : TNFSF10 (TNF superfamily member 10)
Heterocephalus glaber (naked mole-rat) : Tnfsf10 (TNF superfamily member 10)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl327,317,028 - 27,342,427 (+)EnsemblGRCm38mm10GRCm38
GRCm38327,317,077 - 27,339,665 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37327,215,999 - 27,238,587 (+)NCBIGRCm37mm9NCBIm37
MGSCv36327,508,150 - 27,530,738 (+)NCBImm8
Celera327,279,765 - 27,300,536 (+)NCBICelera
Cytogenetic Map3A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Tnfsf10
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732827
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.