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Gene: Tnfsf10 (tumor necrosis factor (ligand) superfamily, member 10) Mus musculus
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Symbol: Tnfsf10
Name: tumor necrosis factor (ligand) superfamily, member 10
Description: Exhibits TRAIL binding activity and tumor necrosis factor receptor superfamily binding activity. Involved in positive regulation of extrinsic apoptotic signaling pathway. Predicted to localize to extracellular space; integral component of membrane; and plasma membrane. Is expressed in central nervous system; renal vasculature; and retina. Human ortholog(s) of this gene implicated in arteriosclerosis and small cell carcinoma. Orthologous to human TNFSF10 (TNF superfamily member 10); PARTICIPATES IN Trail mediated signaling pathway; apoptotic cell death pathway; influenza A pathway; INTERACTS WITH 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: A330042I21Rik; AI448571; APO-2L; Ly81; TL2; TNF-related apoptosis inducing ligand; TNF-related apoptosis-inducing ligand; Tnlg6a; Trail; TRAIL/APO2L; tumor necrosis factor ligand 6a; tumor necrosis factor ligand superfamily member 10
Orthologs:
Homo sapiens (human) : TNFSF10 (TNF superfamily member 10)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Tnfsf10 (TNF superfamily member 10)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tnfsf10 (TNF superfamily member 10)
Pan paniscus (bonobo/pygmy chimpanzee) : TNFSF10 (TNF superfamily member 10)
Canis lupus familiaris (dog) : TNFSF10 (TNF superfamily member 10)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tnfsf10 (TNF superfamily member 10)
Sus scrofa (pig) : TNFSF10 (TNF superfamily member 10)
Chlorocebus sabaeus (African green monkey) : TNFSF10 (TNF superfamily member 10)
Heterocephalus glaber (naked mole-rat) : Tnfsf10 (TNF superfamily member 10)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl327,317,028 - 27,342,427 (+)EnsemblGRCm38mm10GRCm38
GRCm38327,317,077 - 27,339,665 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37327,215,999 - 27,238,587 (+)NCBIGRCm37mm9NCBIm37
MGSCv36327,508,150 - 27,530,738 (+)NCBImm8
Celera327,279,765 - 27,300,536 (+)NCBICelera
Cytogenetic Map3A3NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Tnfsf10
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732827
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.