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Gene: AKAP4 (A-kinase anchoring protein 4) Homo sapiens
Symbol: AKAP4
Name: A-kinase anchoring protein 4
Description: The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins, which have the common function of binding to the regulatory subunit of protein kinase A (PKA) and confining the holoenzyme to discrete locations within the cell. This gene encodes a member of the AKAP family. The encoded protein is localized to the sperm flagellum and may be involved in the regulation of sperm motility. Alternative splicing of this gene results in two transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 75 kda fibrous sheath protein; A kinase (PRKA) anchor protein 4; A-kinase anchor protein 4; A-kinase anchor protein 82 kDa; AKAP 82; AKAP-4; AKAP82; cancer/testis antigen 99; CT99; FSC1; hAKAP82; HI; major sperm fibrous sheath protein; p82; PRKA4; protein kinase A anchoring protein 4; protein kinase A-anchoring protein 4; testis-specific gene HI
Mus musculus (house mouse) : Akap4 (A kinase (PRKA) anchor protein 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akap4 (A-kinase anchoring protein 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akap4 (A-kinase anchoring protein 4)
Pan paniscus (bonobo/pygmy chimpanzee) : AKAP4 (A-kinase anchoring protein 4)
Canis lupus familiaris (dog) : AKAP4 (A-kinase anchoring protein 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akap4 (A-kinase anchoring protein 4)
Sus scrofa (pig) : AKAP4 (A-kinase anchoring protein 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X50,190,777 - 50,201,007 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X49,955,411 - 49,965,664 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X49,842,151 - 49,852,404 (-)NCBINCBI36hg18NCBI36
Build 34X49,658,457 - 49,668,040NCBI
CeleraX54,024,511 - 54,034,765 (-)NCBI
Cytogenetic MapXp11.22NCBI
HuRefX47,427,699 - 47,437,860 (-)NCBIHuRef
CHM1_1X50,035,048 - 50,045,361 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on AKAP4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732830
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.