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Gene: EIF4E (eukaryotic translation initiation factor 4E) Homo sapiens
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Symbol: EIF4E
Name: eukaryotic translation initiation factor 4E
Description: Exhibits several functions, including RNA binding activity; eukaryotic initiation factor 4G binding activity; and repressing transcription factor binding activity. Involved in G1/S transition of mitotic cell cycle; positive regulation of mitotic cell cycle; and regulation of translation. Localizes to several cellular components, including RISC complex; cytoplasmic ribonucleoprotein granule; and eukaryotic translation initiation factor 4F complex. Implicated in autistic disorder.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AUTS19; CBP; eIF-4E; eIF-4F 25 kDa subunit; EIF4E1; EIF4EL1; EIF4F; eukaryotic translation initiation factor 4E-like 1; MGC111573; mRNA cap-binding protein
Orthologs:
Mus musculus (house mouse) : Eif4e (eukaryotic translation initiation factor 4E)  MGI  Alliance
Rattus norvegicus (Norway rat) : Eif4e (eukaryotic translation initiation factor 4E)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Eif4e (eukaryotic translation initiation factor 4E)
Pan paniscus (bonobo/pygmy chimpanzee) : EIF4E (eukaryotic translation initiation factor 4E)
Canis lupus familiaris (dog) : EIF4E (eukaryotic translation initiation factor 4E)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Eif4e (eukaryotic translation initiation factor 4E)
Sus scrofa (pig) : EIF4E (eukaryotic translation initiation factor 4E)
Chlorocebus sabaeus (African green monkey) : EIF4E (eukaryotic translation initiation factor 4E)
more info ...
Related Pseudogenes: EIF4EP1   EIF4EP2   EIF4EP3   EIF4EP4   EIF4EP5  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl498,871,684 - 98,930,637 (-)EnsemblGRCh38hg38GRCh38
GRCh38498,871,684 - 98,930,637 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37499,799,607 - 99,851,786 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 364100,020,235 - 100,070,139 (-)NCBINCBI36hg18NCBI36
Build 344100,158,390 - 100,208,294NCBI
Celera497,096,811 - 97,149,290 (-)NCBI
Cytogenetic Map4q23NCBI
HuRef495,536,964 - 95,590,638 (-)NCBIHuRef
CHM1_1499,776,200 - 99,828,797 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Disease Annotations
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References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on EIF4E
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732833
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.