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Gene: Il12b (interleukin 12b) Mus musculus
Symbol: Il12b
Name: interleukin 12b
Description: Exhibits interleukin-12 alpha subunit binding activity and protein homodimerization activity. Contributes to cytokine activity and cytokine receptor binding activity. Involved in several processes, including defense response to other organism; positive regulation of adaptive immune response based on somatic recombination of immune receptors built from immunoglobulin superfamily domains; and regulation of defense response. Localizes to several cellular components, including the cell surface; interleukin-12 complex; and interleukin-23 complex. Human ortholog(s) of this gene implicated in asthma; chronic obstructive pulmonary disease; primary immunodeficiency disease; and salmonellosis. Is expressed in colon. Orthologous to human IL12B (interleukin 12B).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CLMF p40; cytotoxic lymphocyte maturation factor 40 kDa subunit; IL-12 p40; IL-12 p40 subunit; IL-12 subunit p40; Il-12b; Il-12p40; IL-23 subunit p40; Il12p40; interleukin-12 p40 subunit; interleukin-12 subunit beta; p40
Homo sapiens (human) : IL12B (interleukin 12B)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Il12b (interleukin 12B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Il12b (interleukin 12B)
Pan paniscus (bonobo/pygmy chimpanzee) : IL12B (interleukin 12B)
Canis lupus familiaris (dog) : IL12B (interleukin 12B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Il12b (interleukin 12B)
Sus scrofa (pig) : IL12B (interleukin 12B)
Chlorocebus sabaeus (green monkey) : IL12B (interleukin 12B)
Heterocephalus glaber (naked mole-rat) : Il12b (interleukin 12B)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1144,400,063 - 44,414,033 (+)Ensembl
GRCm381144,400,063 - 44,414,677 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371144,213,565 - 44,227,519 (+)NCBIGRCm37mm9NCBIm37
MGSCv361144,243,486 - 44,257,440 (+)NCBImm8
Celera1149,032,464 - 49,047,071 (+)NCBICelera
Cytogenetic Map11 B1.1NCBI
cM Map1125.94NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Il12b
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732857
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.