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Gene: Icos (inducible T cell co-stimulator) Mus musculus
Symbol: Icos
Name: inducible T cell co-stimulator
Description: Predicted to be involved in T cell costimulation; T cell tolerance induction; and cell-cell adhesion. Localizes to the external side of plasma membrane and integral component of plasma membrane. Used to study common variable immunodeficiency. Human ortholog(s) of this gene implicated in celiac disease; common variable immunodeficiency; and immunoglobulin alpha deficiency. Orthologous to human ICOS (inducible T cell costimulator); PARTICIPATES IN primary immunodeficiency pathway; T cell receptor signaling pathway; INTERACTS WITH 2,3,7,8-tetrachlorodibenzodioxine; 4,4'-diaminodiphenylmethane; 4-hydroxyphenyl retinamide.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: activation-inducible lymphocyte immunomediatory molecule; AILIM; CCLP; CD28 and CTLA-4-like protein; CD28-related protein 1; CRP-1; H4; inducible T-cell co-stimulator; inducible T-cell costimulator; Ly115
Homo sapiens (human) : ICOS (inducible T cell costimulator)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Icos (inducible T-cell co-stimulator)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Icos (inducible T cell costimulator)
Pan paniscus (bonobo/pygmy chimpanzee) : ICOS (inducible T cell costimulator)
Canis lupus familiaris (dog) : ICOS (inducible T cell costimulator)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Icos (inducible T cell costimulator)
Sus scrofa (pig) : ICOS (inducible T cell costimulator)
Chlorocebus sabaeus (African green monkey) : ICOS (inducible T cell costimulator)
Heterocephalus glaber (naked mole-rat) : Icos (inducible T cell costimulator)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl160,977,927 - 61,000,320 (+)EnsemblGRCm38mm10GRCm38
GRCm38160,960,773 - 61,000,322 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37161,034,758 - 61,057,164 (+)NCBIGRCm37mm9NCBIm37
MGSCv36160,922,469 - 60,943,665 (+)NCBImm8
Celera161,493,037 - 61,515,464 (+)NCBICelera
Cytogenetic Map1C2NCBI
cM Map130.6NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
Nomenclature History
More on Icos
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732863
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.