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Gene: NR0B2 (nuclear receptor subfamily 0 group B member 2) Homo sapiens
Symbol: NR0B2
Name: nuclear receptor subfamily 0 group B member 2
Description: The protein encoded by this gene is an unusual orphan receptor that contains a putative ligand-binding domain but lacks a conventional DNA-binding domain. The gene product is a member of the nuclear hormone receptor family, a group of transcription factors regulated by small hydrophobic hormones, a subset of which do not have known ligands and are referred to as orphan nuclear receptors. The protein has been shown to interact with retinoid and thyroid hormone receptors, inhibiting their ligand-dependent transcriptional activation. In addition, interaction with estrogen receptors has been demonstrated, leading to inhibition of function. Studies suggest that the protein represses nuclear hormone receptor-mediated transactivation via two separate steps: competition with coactivators and the direct effects of its transcriptional repressor function. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ17090; nuclear receptor SHP; nuclear receptor subfamily 0, group B, member 2; orphan nuclear receptor SHP; SHP; SHP1; small heterodimer partner
Mus musculus (house mouse) : Nr0b2 (nuclear receptor subfamily 0, group B, member 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Nr0b2 (nuclear receptor subfamily 0, group B, member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr0b2 (nuclear receptor subfamily 0 group B member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Canis lupus familiaris (dog) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr0b2 (nuclear receptor subfamily 0 group B member 2)
Sus scrofa (pig) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38126,911,489 - 26,914,110 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37127,237,975 - 27,240,567 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36127,110,566 - 27,113,047 (-)NCBINCBI36hg18NCBI36
Build 34126,922,120 - 26,924,602NCBI
Celera125,635,071 - 25,637,663 (-)NCBI
Cytogenetic Map1p36.11NCBI
HuRef125,491,554 - 25,494,146 (-)NCBIHuRef
CHM1_1127,351,340 - 27,353,932 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Candidate Gene Status
Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on NR0B2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732873
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.