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Gene: Nr0b2 (nuclear receptor subfamily 0, group B, member 2) Mus musculus
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Symbol: Nr0b2
Name: nuclear receptor subfamily 0, group B, member 2
Description: This gene encodes a member of the nuclear hormone receptor family of proteins. The encoded orphan receptor lacks a DNA binding domain but modulates gene expression by interacting with other hormone receptors to competitively inhibit binding of coactivators while also acting as a transcriptional corepressor. The encoded receptor may regulate bile acid synthesis and sexual maturation in males. Homozygous knockout mice exhibit accumulation of bile acids, reduced levels of low density lipoprotein cholesterol (LDL-C), and in male mice, earlier testicular maturation. [provided by RefSeq, Aug 2015]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: nuclear receptor subfamily 0 group B member 2; orphan nuclear receptor SHP; SHP; SHP-1; Shp1; small heterodimer partner
Orthologs:
Homo sapiens (human) : NR0B2 (nuclear receptor subfamily 0 group B member 2)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Nr0b2 (nuclear receptor subfamily 0, group B, member 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Nr0b2 (nuclear receptor subfamily 0 group B member 2)
Pan paniscus (bonobo/pygmy chimpanzee) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Canis lupus familiaris (dog) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Nr0b2 (nuclear receptor subfamily 0 group B member 2)
Sus scrofa (pig) : NR0B2 (nuclear receptor subfamily 0 group B member 2)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm384133,553,376 - 133,556,686 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv374133,109,305 - 133,112,451 (+)NCBIGRCm37mm9NCBIm37
MGSCv364132,825,466 - 132,828,612 (+)NCBImm8
Celera4131,722,949 - 131,726,070 (+)NCBICelera
Cytogenetic Map4 D2.3NCBI
cM Map466.25NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Nr0b2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732874
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-17
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.