Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: SH3KBP1 (SH3 domain containing kinase binding protein 1) Homo sapiens
Symbol: SH3KBP1
Name: SH3 domain containing kinase binding protein 1
Description: This gene encodes an adapter protein that contains one or more N-terminal Src homology domains, a proline rich region and a C-terminal coiled-coil domain. The encoded protein facilitates protein-protein interactions and has been implicated in numerous cellular processes including apoptosis, cytoskeletal rearrangement, cell adhesion and in the regulation of clathrin-dependent endocytosis. Alternate splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGMX2; c-Cbl-interacting protein; cbl-interacting protein of 85 kDa; CD2-binding protein 3; CD2BP3; CIN85; GIG10; HSB-1; HSB1; human Src family kinase-binding protein 1; IMD61; MIG18; migration-inducing gene 18; SH3 domain-containing kinase-binding protein 1; SH3-domain kinase binding protein 1; Src family kinase-binding protein 1; src-related kinase binding protein-1
Mus musculus (house mouse) : Sh3kbp1 (SH3-domain kinase binding protein 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh3kbp1 (SH3 domain-containing kinase-binding protein 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh3kbp1 (SH3 domain containing kinase binding protein 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SH3KBP1 (SH3 domain containing kinase binding protein 1)
Canis lupus familiaris (dog) : SH3KBP1 (SH3 domain containing kinase binding protein 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh3kbp1 (SH3 domain containing kinase binding protein 1)
Sus scrofa (pig) : SH3KBP1 (SH3 domain containing kinase binding protein 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38X19,533,965 - 19,887,626 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37X19,552,083 - 19,905,744 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36X19,463,441 - 19,815,640 (-)NCBINCBI36hg18NCBI36
Build 34X19,313,176 - 19,665,376NCBI
CeleraX23,675,636 - 24,008,177 (-)NCBI
Cytogenetic MapXp22.12NCBI
HuRefX17,300,128 - 17,651,187 (-)NCBIHuRef
CHM1_1X19,582,478 - 19,936,208 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SH3KBP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732890
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-07-09
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.