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Gene: PDGFRB (platelet derived growth factor receptor beta) Homo sapiens
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Symbol: PDGFRB
Name: platelet derived growth factor receptor beta
CRRD ID: 732897
Description: Exhibits several functions, including growth factor binding activity; platelet-derived growth factor beta-receptor activity; and platelet-derived growth factor receptor binding activity. Involved in several processes, including platelet-derived growth factor receptor signaling pathway; positive regulation of phosphate metabolic process; and protein phosphorylation. Localizes to Golgi apparatus and intrinsic component of plasma membrane. Implicated in basal ganglia calcification; glioblastoma multiforme; infantile myofibromatosis; myeloproliferative neoplasm (multiple); and renal cell carcinoma. Biomarker of Kuhnt-Junius degeneration; breast cancer (multiple); renal cell carcinoma; and reproductive organ cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: Activated tyrosine kinase PDGFRB; beta-type platelet-derived growth factor receptor; CD140 antigen-like family member B; CD140B; IBGC4; IMF1; JTK12; KOGS; NDEL1-PDGFRB; PDGF-R-beta; PDGFR; PDGFR-1; PDGFR-beta; PDGFR1; PENTT; platelet-derived growth factor receptor 1; platelet-derived growth factor receptor beta; platelet-derived growth factor receptor, beta polypeptide
Orthologs:
Mus musculus (house mouse) : Pdgfrb (platelet derived growth factor receptor, beta polypeptide)  MGI  Alliance
Rattus norvegicus (Norway rat) : Pdgfrb (platelet derived growth factor receptor beta)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Pdgfrb (platelet derived growth factor receptor beta)
Pan paniscus (bonobo/pygmy chimpanzee) : PDGFRB (platelet derived growth factor receptor beta)
Canis lupus familiaris (dog) : PDGFRB (platelet derived growth factor receptor beta)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Pdgfrb (platelet derived growth factor receptor beta)
Sus scrofa (pig) : PDGFRB (platelet derived growth factor receptor beta)
Chlorocebus sabaeus (African green monkey) : PDGFRB (platelet derived growth factor receptor beta)
Heterocephalus glaber (naked mole-rat) : Pdgfrb (platelet derived growth factor receptor beta)
more info ...
Allele / Splice: See ClinVar data
Is Marker For: QTLs:   AASTH54_H  
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5150,113,839 - 150,155,872 (-)EnsemblGRCh38hg38GRCh38
GRCh385150,113,839 - 150,155,845 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375149,493,402 - 149,535,447 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365149,473,595 - 149,515,615 (-)NCBINCBI36hg18NCBI36
Build 345149,473,595 - 149,515,503NCBI
Celera5145,574,776 - 145,616,798 (-)NCBI
Cytogenetic Map5q32NCBI
HuRef5144,641,381 - 144,683,476 (-)NCBIHuRef
CHM1_15148,925,983 - 148,968,003 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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Genomics

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RNA-SEQ Expression

Sequence

Nucleotide Sequences
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Additional Information

External Database Links
Nomenclature History
 
More on PDGFRB
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732897
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.