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Gene: AKT1 (AKT serine/threonine kinase 1) Homo sapiens
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Symbol: AKT1
Name: AKT serine/threonine kinase 1
Description: Exhibits several functions, including 14-3-3 protein binding activity; phosphatidylinositol phosphate binding activity; and protein kinase activity. Involved in several processes, including intracellular signal transduction; negative regulation of cellular metabolic process; and positive regulation of cellular metabolic process. Localizes to several cellular components, including the cytosol; microtubule cytoskeleton; and nucleoplasm. Implicated in several diseases, including Cowden syndrome; Proteus syndrome; breast cancer (multiple); endocrine gland cancer (multiple); and prostate cancer (multiple). Biomarker of several diseases, including Parkinson's disease; astrocytoma; coronary artery disease (multiple); pancreatic cancer; and urinary system cancer (multiple).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AKT; AKT1m; CWS6; MGC99656; PKB; PKB alpha; PKB-ALPHA; PRKBA; protein kinase B; protein kinase B alpha; proto-oncogene c-Akt; RAC; rac protein kinase alpha; RAC-ALPHA; RAC-alpha serine/threonine-protein kinase; RAC-PK-alpha; serine-threonine protein kinase; v-akt murine thymoma viral oncogene homolog 1; v-akt murine thymoma viral oncogene-like protein 1
Orthologs:
Mus musculus (house mouse) : Akt1 (thymoma viral proto-oncogene 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Akt1 (AKT serine/threonine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Akt1 (AKT serine/threonine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : AKT1 (AKT serine/threonine kinase 1)
Canis lupus familiaris (dog) : AKT1 (AKT serine/threonine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Akt1 (AKT serine/threonine kinase 1)
Sus scrofa (pig) : AKT1 (AKT serine/threonine kinase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl14104,769,349 - 104,795,751 (-)Ensembl
GRCh3814104,769,349 - 104,795,748 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3714105,235,686 - 105,262,080 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3614104,306,731 - 104,333,125 (-)NCBINCBI36hg18NCBI36
Build 3414104,306,752 - 104,330,608NCBI
Celera1485,290,760 - 85,317,154 (-)NCBI
Cytogenetic Map14q32.33NCBI
HuRef1485,432,617 - 85,464,212 (-)NCBIHuRef
CHM1_114105,173,739 - 105,200,089 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model