Symbol:
P3H4
Name:
prolyl 3-hydroxylase family member 4 (inactive)
Description:
Predicted to be involved in several processes, including collagen biosynthetic process; collagen fibril organization; and peptidyl-lysine hydroxylation. Localizes to the endoplasmic reticulum.
Type:
protein-coding
RefSeq Status:
VALIDATED
Also known as:
endoplasmic reticulum protein SC65; leprecan-like 4; leprecan-like protein 4; LEPREL4; NO55; NOL55; nucleolar autoantigen (55kD); nucleolar autoantigen No55; nucleolar autoantigen, 55kDa; prolyl 3-hydroxylase family member 4 (non-enzymatic); SC65; synaptonemal complex 65; synaptonemal complex protein SC65
Orthologs:
Species
Gene symbol and name
Data Source
Assertion derived from
less info ...
Orthologs 1
Mus musculus (house mouse):
P3h4 (prolyl 3-hydroxylase family member 4 (non-enzymatic)) HGNC
Ensembl, HGNC, HomoloGene, Inparanoid, NCBI, OMA, OrthoDB, Panther, Treefam
Rattus norvegicus (Norway rat):
P3h4 (prolyl 3-hydroxylase family member 4 (non-enzymatic)) HGNC
Ensembl, HomoloGene, NCBI, OMA, OrthoDB, Panther
Chinchilla lanigera (long-tailed chinchilla):
P3h4 (prolyl 3-hydroxylase family member 4 (inactive)) NCBI
Ortholog
Pan paniscus (bonobo/pygmy chimpanzee):
P3H4 (prolyl 3-hydroxylase family member 4 (inactive)) NCBI
Ortholog
Canis lupus familiaris (dog):
P3H4 (prolyl 3-hydroxylase family member 4 (inactive)) HGNC
EggNOG, Ensembl, HomoloGene, NCBI, OMA, OrthoDB, OrthoMCL, Panther, Treefam
Ictidomys tridecemlineatus (thirteen-lined ground squirrel):
P3h4 (prolyl 3-hydroxylase family member 4 (inactive)) NCBI
Ortholog
Sus scrofa (pig):
P3H4 (prolyl 3-hydroxylase family member 4 (inactive)) HGNC
EggNOG, Ensembl, NCBI, OMA, OrthoDB, Panther, Treefam
Other homologs 2
Mus musculus (house mouse):
Crtap (cartilage associated protein) HGNC
OrthoDB
Rattus norvegicus (Norway rat):
Crtapl1 (cartilage associated protein-like 1) HGNC
OrthoDB
Canis lupus familiaris (dog):
CRTAP (cartilage associated protein) HGNC
OrthoDB
Sus scrofa (pig):
CRTAP (cartilage associated protein) HGNC
OrthoDB
Alliance orthologs 3
Rattus norvegicus (Norway rat):
P3h4 (prolyl 3-hydroxylase family member 4 (non-enzymatic))
Alliance
DIOPT (Ensembl Compara, HGNC, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER)
Mus musculus (house mouse):
P3h4 (prolyl 3-hydroxylase family member 4 (non-enzymatic))
Alliance
DIOPT (Ensembl Compara, HGNC, Hieranoid, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam)
Danio rerio (zebrafish):
p3h4 (prolyl 3-hydroxylase family member 4 (non-enzymatic))
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, Roundup, TreeFam, ZFIN)
Caenorhabditis elegans (roundworm):
Y73F8A.26
Alliance
DIOPT (Ensembl Compara, InParanoid, OMA, OrthoFinder, OrthoInspector, PANTHER, PhylomeDB, TreeFam)
Allele / Splice:
See ClinVar data
Latest Assembly:
GRCh38 - Human Genome Assembly GRCh38
Position:
Human Assembly Chr Position (strand) Source Genome Browsers JBrowse NCBI UCSC Ensembl GRCh38 17 41,801,952 - 41,812,710 (-) NCBI GRCh38 GRCh38 hg38 GRCh38 GRCh37 17 39,958,204 - 39,968,881 (-) NCBI GRCh37 GRCh37 hg19 GRCh37 Build 36 17 37,211,731 - 37,221,977 (-) NCBI NCBI36 hg18 NCBI36 Build 34 17 37,211,731 - 37,221,977 NCBI Celera 17 36,609,515 - 36,619,798 (-) NCBI Cytogenetic Map 17 q21.2 NCBI HuRef 17 35,720,169 - 35,730,452 (-) NCBI HuRef CHM1_1 17 40,193,805 - 40,204,052 (-) NCBI CHM1_1
JBrowse:
View Region in Genome Browser (JBrowse)
Model
Gene-Chemical Interaction Annotations
1,3-dinitrobenzene increases expression ISO RGD:620767 6480464 3-dinitrobenzene results in increased expression of P3H4 mRNA CTD PMID:21983209 2,2',4,4'-Tetrabromodiphenyl ether decreases expression EXP 6480464 2 more ... CTD PMID:23146750 2,3,7,8-tetrachlorodibenzodioxine decreases expression ISO RGD:620767 6480464 Tetrachlorodibenzodioxin results in decreased expression of P3H4 mRNA CTD PMID:11752688 2-methylcholine affects expression EXP 6480464 beta-methylcholine affects the expression of P3H4 mRNA CTD PMID:21179406 3H-1,2-dithiole-3-thione increases expression ISO RGD:620767 6480464 1, 2-dithiol-3-thione results in increased expression of P3H4 mRNA CTD PMID:19162173 6-propyl-2-thiouracil increases expression ISO RGD:620767 6480464 Propylthiouracil results in increased expression of P3H4 mRNA CTD PMID:24780913 aflatoxin B1 decreases expression EXP 6480464 Aflatoxin B1 results in decreased expression of P3H4 mRNA CTD PMID:27153756 aflatoxin B1 increases methylation EXP 6480464 Aflatoxin B1 results in increased methylation of P3H4 intron CTD PMID:30157460 aflatoxin B2 decreases methylation EXP 6480464 aflatoxin B2 results in decreased methylation of P3H4 polyA tail CTD PMID:30157460 ammonium chloride affects expression ISO RGD:620767 6480464 Ammonium Chloride affects the expression of P3H4 mRNA CTD PMID:16483693 benzo[a]pyrene affects methylation EXP 6480464 Benzo(a)pyrene affects the methylation of P3H4 intron CTD PMID:30157460 bis(2-ethylhexyl) phthalate decreases expression EXP 6480464 Diethylhexyl Phthalate results in decreased expression of P3H4 protein CTD PMID:31163220 bisphenol A decreases expression EXP 6480464 bisphenol A results in decreased expression of P3H4 mRNA CTD PMID:23146750 bisphenol A affects expression ISO RGD:620767 6480464 bisphenol A affects the expression of P3H4 mRNA CTD PMID:25181051 bisphenol A increases expression EXP 6480464 bisphenol A results in increased expression of P3H4 mRNA CTD PMID:25047013 C60 fullerene increases expression ISO RGD:620767 6480464 fullerene C60 results in increased expression of P3H4 mRNA CTD PMID:19167457 cadmium dichloride increases expression ISO RGD:620767 6480464 Cadmium Chloride results in increased expression of P3H4 mRNA CTD PMID:21297351 cobalt dichloride decreases expression EXP 6480464 cobaltous chloride results in decreased expression of P3H4 mRNA CTD PMID:19376846 copper atom multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in increased expression of P3H4 mRNA CTD PMID:24690739 copper(0) multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in increased expression of P3H4 mRNA CTD PMID:24690739 copper(II) chloride affects expression EXP 6480464 cupric chloride affects the expression of P3H4 mRNA CTD PMID:17211630 copper(II) sulfate decreases expression EXP 6480464 Copper Sulfate results in decreased expression of P3H4 mRNA CTD PMID:19549813 crocidolite asbestos decreases expression EXP 6480464 Asbestos, Crocidolite results in decreased expression of P3H4 mRNA CTD PMID:29523930 cyclosporin A decreases expression EXP 6480464 Cyclosporine results in decreased expression of P3H4 mRNA CTD PMID:25562108 dibutyl phthalate decreases expression ISO RGD:620767 6480464 Dibutyl Phthalate results in decreased expression of P3H4 mRNA CTD PMID:21266533 disulfiram multiple interactions EXP 6480464 [Disulfiram binds to Copper] which results in increased expression of P3H4 mRNA CTD PMID:24690739 furan increases methylation ISO RGD:620767 6480464 furan results in increased methylation of P3H4 gene CTD PMID:22079235 hydrogen peroxide affects expression EXP 6480464 Hydrogen Peroxide affects the expression of P3H4 mRNA CTD PMID:21179406 orphenadrine affects expression ISO RGD:620767 6480464 Orphenadrine affects the expression of P3H4 mRNA CTD PMID:23665939 oxaliplatin multiple interactions ISO RGD:620767 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of P3H4 mRNA CTD PMID:25729387 perfluorooctanoic acid decreases expression EXP 6480464 perfluorooctanoic acid results in decreased expression of P3H4 mRNA, perfluorooctanoic acid results in decreased expression of P3H4 protein CTD PMID:23146750 , PMID:26879310 pirinixic acid increases expression ISO RGD:735364 6480464 pirinixic acid results in increased expression of P3H4 mRNA CTD PMID:20813756 , PMID:23811191 potassium dichromate increases expression ISO RGD:735364 6480464 Potassium Dichromate results in increased expression of P3H4 mRNA CTD PMID:23608068 quercetin decreases expression ISO RGD:735364 6480464 Quercetin results in decreased expression of P3H4 mRNA CTD PMID:25862958 sodium arsenite decreases expression EXP 6480464 sodium arsenite results in decreased expression of P3H4 mRNA CTD PMID:20371982 sodium arsenite increases expression ISO RGD:620767 6480464 sodium arsenite results in increased expression of P3H4 protein CTD PMID:19072884 Soman increases expression ISO RGD:620767 6480464 Soman results in increased expression of P3H4 mRNA CTD PMID:19281266 testosterone enanthate affects expression EXP 6480464 testosterone enanthate affects the expression of P3H4 mRNA CTD PMID:17440010 thapsigargin decreases expression ISO RGD:735364 6480464 Thapsigargin results in decreased expression of P3H4 protein CTD PMID:24648495 titanium dioxide decreases expression ISO RGD:735364 6480464 titanium dioxide results in decreased expression of P3H4 mRNA CTD PMID:23557971 topotecan multiple interactions ISO RGD:620767 6480464 [oxaliplatin co-treated with Topotecan] results in increased expression of P3H4 mRNA CTD PMID:25729387 topotecan increases expression ISO RGD:620767 6480464 Topotecan results in increased expression of P3H4 mRNA CTD PMID:25729387 trimellitic anhydride decreases expression ISO RGD:735364 6480464 trimellitic anhydride results in decreased expression of P3H4 mRNA CTD PMID:19042947 urethane decreases expression EXP 6480464 Urethane results in decreased expression of P3H4 mRNA CTD PMID:28818685 valproic acid decreases expression EXP 6480464 Valproic Acid results in decreased expression of P3H4 mRNA CTD PMID:23179753 more ... valproic acid increases methylation EXP 6480464 Valproic Acid results in increased methylation of P3H4 gene CTD PMID:29154799 valproic acid affects expression EXP 6480464 Valproic Acid affects the expression of P3H4 mRNA CTD PMID:25979313 
Gene Ontology Annotations
