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Gene: SLC6A4 (solute carrier family 6 member 4) Homo sapiens
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Symbol: SLC6A4
Name: solute carrier family 6 member 4
Description: This gene encodes an integral membrane protein that transports the neurotransmitter serotonin from synaptic spaces into presynaptic neurons. The encoded protein terminates the action of serotonin and recycles it in a sodium-dependent manner. This protein is a target of psychomotor stimulants, such as amphetamines and cocaine, and is a member of the sodium:neurotransmitter symporter family. A repeat length polymorphism in the promoter of this gene has been shown to affect the rate of serotonin uptake. There have been conflicting results in the literature about the possible effect, if any, that this polymorphism may play in behavior and depression. [provided by RefSeq, May 2019]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 5-HTT; 5-HTTLPR; 5-hydroxytryptamine (serotonin) transporter; 5-hydroxytryptamine transporter; 5HT transporter; 5HTT; hSERT; HTT; Na+/Cl- dependent serotonin transporter; obsessive-compulsive disorder 1; OCD1; serotonin transporter 1; SERT; SERT1; sodium-dependent serotonin transporter; solute carrier family 6 (neurotransmitter transporter), member 4; solute carrier family 6 (neurotransmitter transporter, serotonin), member 4; solute carrier family 6, member 4
Orthologs:
Mus musculus (house mouse) : Slc6a4 (solute carrier family 6 (neurotransmitter transporter, serotonin), member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc6a4 (solute carrier family 6 member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc6a4 (solute carrier family 6 member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC6A4 (solute carrier family 6 member 4)
Canis lupus familiaris (dog) : SLC6A4 (solute carrier family 6 member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc6a4 (solute carrier family 6 member 4)
Sus scrofa (pig) : SLC6A4 (solute carrier family 6 member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381730,194,319 - 30,235,697 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371728,521,337 - 28,562,986 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361725,549,032 - 25,586,841 (-)NCBINCBI36hg18NCBI36
Build 341725,549,031 - 25,586,831NCBI
Celera1725,385,103 - 25,424,627 (-)NCBI
Cytogenetic Map17q11.2NCBI
HuRef1724,731,684 - 24,773,327 (-)NCBIHuRef
CHM1_11728,583,810 - 28,625,471 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC6A4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732932
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-10-08
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.