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Gene: DUSP1 (dual specificity phosphatase 1) Homo sapiens
Symbol: DUSP1
Name: dual specificity phosphatase 1
CRRD ID: 732954
Description: Exhibits protein tyrosine phosphatase activity and protein tyrosine/serine/threonine phosphatase activity. Involved in several processes, including negative regulation of MAPK cascade; negative regulation of monocyte chemotaxis; and peptidyl-tyrosine dephosphorylation. Localizes to cytoplasm and nucleus. Implicated in breast cancer. Biomarker of several diseases, including breast cancer; major depressive disorder; psoriasis; reproductive organ cancer (multiple); and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CL 100; CL100; dual specificity protein phosphatase 1; dual specificity protein phosphatase hVH1; HVH1; MAP kinase phosphatase 1; mitogen-activated protein kinase phosphatase 1; MKP-1; MKP1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase CL100; PTPN10; serine/threonine specific protein phosphatase
Mus musculus (house mouse) : Dusp1 (dual specificity phosphatase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dusp1 (dual specificity phosphatase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp1 (dual specificity phosphatase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP1 (dual specificity phosphatase 1)
Canis lupus familiaris (dog) : DUSP1 (dual specificity phosphatase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp1 (dual specificity phosphatase 1)
Sus scrofa (pig) : DUSP1 (dual specificity phosphatase 1)
Chlorocebus sabaeus (African green monkey) : DUSP1 (dual specificity phosphatase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl5172,768,096 - 172,771,195 (-)EnsemblGRCh38hg38GRCh38
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375172,195,093 - 172,198,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DUSP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732954
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.