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Gene: DUSP1 (dual specificity phosphatase 1) Homo sapiens
Symbol: DUSP1
Name: dual specificity phosphatase 1
Description: The protein encoded by this gene is a phosphatase with dual specificity for tyrosine and threonine. The encoded protein can dephosphorylate MAP kinase MAPK1/ERK2, which results in its involvement in several cellular processes. This protein appears to play an important role in the human cellular response to environmental stress as well as in the negative regulation of cellular proliferation. Finally, the encoded protein can make some solid tumors resistant to both chemotherapy and radiotherapy, making it a target for cancer therapy. [provided by RefSeq, Aug 2017]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CL 100; CL100; dual specificity protein phosphatase 1; dual specificity protein phosphatase hVH1; HVH1; MAP kinase phosphatase 1; mitogen-activated protein kinase phosphatase 1; MKP-1; MKP1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase CL100; PTPN10; serine/threonine specific protein phosphatase
Mus musculus (house mouse) : Dusp1 (dual specificity phosphatase 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Dusp1 (dual specificity phosphatase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp1 (dual specificity phosphatase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP1 (dual specificity phosphatase 1)
Canis lupus familiaris (dog) : DUSP1 (dual specificity phosphatase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp1 (dual specificity phosphatase 1)
Sus scrofa (pig) : DUSP1 (dual specificity phosphatase 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh385172,768,096 - 172,771,195 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh375172,195,093 - 172,198,203 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 365172,127,707 - 172,130,809 (-)NCBINCBI36hg18NCBI36
Build 345172,127,706 - 172,130,809NCBI
Celera5168,227,970 - 168,231,080 (-)NCBI
Cytogenetic Map5q35.1NCBI
HuRef5167,290,428 - 167,293,538 (-)NCBIHuRef
CHM1_15171,627,607 - 171,630,717 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on DUSP1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732954
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-17
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.