Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Dusp1 (dual specificity phosphatase 1) Mus musculus
Symbol: Dusp1
Name: dual specificity phosphatase 1
Description: Exhibits mitogen-activated protein kinase binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of MAPK cascade; negative regulation of cell population proliferation; and protein dephosphorylation. Predicted to localize to cytoplasm and nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; limb; and sensory organ. Human ortholog(s) of this gene implicated in breast cancer. Orthologous to human DUSP1 (dual specificity phosphatase 1); PARTICIPATES IN angiotensin II signaling pathway via AT2 receptor; c-Jun N-terminal kinases MAPK signaling pathway; p38 MAPK signaling pathway; INTERACTS WITH (S)-nicotine; 17beta-estradiol; 2,3',4,4',5-Pentachlorobiphenyl.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 3CH134; dual specificity protein phosphatase 1; erp; MAP kinase phosphatase 1; mitogen-activated protein kinase phosphatase 1; mitogen-activated protein kinase phosphatase-1; mkp-1; MKP1; protein tyrosine phosphatase, non-receptor type 16; protein-tyrosine phosphatase 3CH134; protein-tyrosine phosphatase ERP; Ptpn16; U19515
Homo sapiens (human) : DUSP1 (dual specificity phosphatase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Dusp1 (dual specificity phosphatase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Dusp1 (dual specificity phosphatase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : DUSP1 (dual specificity phosphatase 1)
Canis lupus familiaris (dog) : DUSP1 (dual specificity phosphatase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Dusp1 (dual specificity phosphatase 1)
Sus scrofa (pig) : DUSP1 (dual specificity phosphatase 1)
Chlorocebus sabaeus (African green monkey) : DUSP1 (dual specificity phosphatase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl1726,505,590 - 26,562,128 (-)EnsemblGRCm38mm10GRCm38
GRCm381726,505,591 - 26,508,472 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371726,642,536 - 26,645,417 (-)NCBIGRCm37mm9NCBIm37
MGSCv361726,233,191 - 26,236,061 (-)NCBImm8
Celera1727,037,972 - 27,040,854 (-)NCBICelera
Cytogenetic Map17A3.3NCBI
cM Map1713.28NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Dusp1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732955
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-06-30
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.