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Gene: CFL1 (cofilin 1) Homo sapiens
Symbol: CFL1
Name: cofilin 1
CRRD ID: 732970
Description: Exhibits actin filament binding activity. Involved in several processes, including actin filament depolymerization; positive regulation by host of viral process; and regulation of dendritic spine morphogenesis. Localizes to cytoplasm and focal adhesion. Biomarker of brain compression and gallbladder carcinoma.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 18 kDa phosphoprotein; CFL; cofilin; cofilin 1 (non-muscle); cofilin, non-muscle isoform; cofilin-1; epididymis secretory protein Li 15; HEL-S-15; p18
Mus musculus (house mouse) : Cfl1 (cofilin 1, non-muscle)  MGI  Alliance
Rattus norvegicus (Norway rat) : Cfl1 (cofilin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Cfl1 (cofilin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : CFL1 (cofilin 1)
Canis lupus familiaris (dog) : CFL1 (cofilin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Cfl1 (cofilin 1)
Sus scrofa (pig) : CFL1 (cofilin 1)
Chlorocebus sabaeus (African green monkey) : CFL1 (cofilin 1)
Heterocephalus glaber (naked mole-rat) : Cfl1 (cofilin 1)
more info ...
Related Pseudogenes: CFL1P1   CFL1P2   CFL1P3   CFL1P4   CFL1P5   CFL1P6   CFL1P7   CFL1P8  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1165,823,022 - 65,862,026 (-)EnsemblGRCh38hg38GRCh38
GRCh381165,854,673 - 65,858,180 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371165,622,282 - 65,625,804 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361165,378,858 - 65,382,380 (-)NCBINCBI36hg18NCBI36
Build 341165,378,862 - 65,382,380NCBI
Celera1162,946,188 - 62,949,710 (-)NCBI
Cytogenetic Map11q13.1NCBI
HuRef1161,948,799 - 61,952,321 (-)NCBIHuRef
CHM1_11165,506,695 - 65,510,217 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on CFL1
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732970
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.