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Gene: PLCG2 (phospholipase C gamma 2) Homo sapiens
Symbol: PLCG2
Name: phospholipase C gamma 2
CRRD ID: 732989
Description: Exhibits phosphatidylinositol phospholipase C activity and phosphotyrosine residue binding activity. Involved in phosphatidylinositol biosynthetic process and release of sequestered calcium ion into cytosol. Localizes to plasma membrane. Implicated in familial cold autoinflammatory syndrome 3.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma-2; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2; APLAID; FCAS3; phosphoinositide phospholipase C-gamma-2; phospholipase c, gamma 2; phospholipase C, gamma 2 (phosphatidylinositol-specific); phospholipase C, gamma 2 (phosphatidylyinositol-specific); phospholipase C-gamma-2; phospholipase C-IV; PLC-gamma-2; PLC-IV; RP11-510J16.3
Mus musculus (house mouse) : Plcg2 (phospholipase C, gamma 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plcg2 (phospholipase C, gamma 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcg2 (phospholipase C gamma 2)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCG2 (phospholipase C gamma 2)
Canis lupus familiaris (dog) : PLCG2 (phospholipase C gamma 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcg2 (phospholipase C gamma 2)
Sus scrofa (pig) : PLCG2 (phospholipase C gamma 2)
Chlorocebus sabaeus (African green monkey) : PLCG2 (phospholipase C gamma 2)
Heterocephalus glaber (naked mole-rat) : Plcg2 (phospholipase C gamma 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1681,739,097 - 81,962,685 (+)EnsemblGRCh38hg38GRCh38
GRCh381681,779,291 - 81,962,685 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371681,812,899 - 81,996,290 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361680,362,768 - 80,549,400 (+)NCBINCBI36hg18NCBI36
Build 341680,370,430 - 80,549,399NCBI
Celera1666,110,768 - 66,289,752 (+)NCBI
Cytogenetic Map16q23.3NCBI
HuRef1667,566,775 - 67,745,459 (+)NCBIHuRef
CHM1_11683,224,217 - 83,407,660 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PLCG2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732989
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-09-16
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.