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Gene: PPIB (peptidylprolyl isomerase B) Homo sapiens
Symbol: PPIB
Name: peptidylprolyl isomerase B
CRRD ID: 732990
Description: Exhibits RNA polymerase binding activity; cyclosporin A binding activity; and peptidyl-prolyl cis-trans isomerase activity. Predicted to contribute to collagen binding activity. Involved in several processes, including neutrophil chemotaxis; positive regulation by host of viral genome replication; and protein stabilization. Localizes to endoplasmic reticulum; nucleoplasm; and perinuclear region of cytoplasm. Implicated in osteogenesis imperfecta type 9.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: B; cyclophilin b; cyclophilin-like protein; CYP-S1; CYPB; epididymis secretory protein Li 39; HEL-S-39; MGC14109; MGC2224; OI9; peptidyl-prolyl cis-trans isomerase B; peptidylprolyl isomerase B (cyclophilin B); PPIase B; rotamase B; S-cyclophilin; SCYLP
Mus musculus (house mouse) : Ppib (peptidylprolyl isomerase B)  MGI  Alliance
Rattus norvegicus (Norway rat) : Ppib (peptidylprolyl isomerase B)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Ppib (peptidylprolyl isomerase B)
Pan paniscus (bonobo/pygmy chimpanzee) : PPIB (peptidylprolyl isomerase B)
Canis lupus familiaris (dog) : PPIB (peptidylprolyl isomerase B)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Ppib (peptidylprolyl isomerase B)
Sus scrofa (pig) : PPIB (peptidylprolyl isomerase B)
Chlorocebus sabaeus (African green monkey) : PPIB (peptidylprolyl isomerase B)
Heterocephalus glaber (naked mole-rat) : Ppib (peptidylprolyl isomerase B)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl1564,155,812 - 64,163,205 (-)EnsemblGRCh38hg38GRCh38
GRCh38.p13 Ensembl1564,155,817 - 64,163,022 (-)EnsemblGRCh38hg38GRCh38
GRCh381564,155,817 - 64,163,022 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh371564,448,014 - 64,455,354 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 361562,235,067 - 62,242,407 (-)NCBINCBI36hg18NCBI36
Build 341562,235,067 - 62,242,407NCBI
Celera1541,326,958 - 41,334,299 (-)NCBI
Cytogenetic Map15q22.31NCBI
HuRef1541,272,716 - 41,280,027 (-)NCBIHuRef
CHM1_11564,567,543 - 64,574,883 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on PPIB
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 732990
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.