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Gene: SLIT2 (slit guidance ligand 2) Homo sapiens
Symbol: SLIT2
Name: slit guidance ligand 2
CRRD ID: 733021
Description: Exhibits several functions, including GTPase inhibitor activity; Roundabout binding activity; and heparin binding activity. Involved in several processes, including generation of neurons; negative regulation of cell migration; and negative regulation of signal transduction. Localizes to cell surface; cytoplasm; and extracellular space.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ14420; SLIL3; slit homolog 2 protein; Slit-2
Mus musculus (house mouse) : Slit2 (slit guidance ligand 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slit2 (slit guidance ligand 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slit2 (slit guidance ligand 2)
Pan paniscus (bonobo/pygmy chimpanzee) : SLIT2 (slit guidance ligand 2)
Canis lupus familiaris (dog) : SLIT2 (slit guidance ligand 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slit2 (slit guidance ligand 2)
Sus scrofa (pig) : SLIT2 (slit guidance ligand 2)
Chlorocebus sabaeus (African green monkey) : SLIT2 (slit guidance ligand 2)
Heterocephalus glaber (naked mole-rat) : Slit2 (slit guidance ligand 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl420,251,905 - 20,620,561 (+)EnsemblGRCh38hg38GRCh38
GRCh38420,251,905 - 20,620,561 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37420,254,566 - 20,622,184 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36419,864,333 - 20,229,886 (+)NCBINCBI36hg18NCBI36
Build 34419,931,503 - 20,297,057NCBI
Celera420,712,350 - 21,077,291 (+)NCBI
Cytogenetic Map4p15.31NCBI
HuRef419,604,199 - 19,969,514 (+)NCBIHuRef
CHM1_1420,251,569 - 20,620,129 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SLIT2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733021
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.