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Gene: ANGPT1 (angiopoietin 1) Homo sapiens
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Symbol: ANGPT1
Name: angiopoietin 1
CRRD ID: 733136
Description: Exhibits receptor tyrosine kinase binding activity. Involved in several processes, including Tie signaling pathway; positive regulation of macromolecule metabolic process; and regulation of vascular permeability. Localizes to several cellular components, including extracellular space; membrane raft; and microvillus. Implicated in brain ischemia; diabetic retinopathy; and hypertension. Biomarker of carcinoma (multiple); hypertension; and ovarian cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AGP1; AGPT; ANG-1; ANG1; angiopoietin-1
Orthologs:
Mus musculus (house mouse) : Angpt1 (angiopoietin 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Angpt1 (angiopoietin 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Angpt1 (angiopoietin 1)
Pan paniscus (bonobo/pygmy chimpanzee) : ANGPT1 (angiopoietin 1)
Canis lupus familiaris (dog) : ANGPT1 (angiopoietin 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Angpt1 (angiopoietin 1)
Sus scrofa (pig) : ANGPT1 (angiopoietin 1)
Chlorocebus sabaeus (African green monkey) : ANGPT1 (angiopoietin 1)
Heterocephalus glaber (naked mole-rat) : Angpt1 (angiopoietin 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl8107,249,482 - 107,498,055 (-)EnsemblGRCh38hg38GRCh38
GRCh388107,249,482 - 107,497,918 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh378108,261,710 - 108,510,254 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 368108,330,886 - 108,579,430 (-)NCBINCBI36hg18NCBI36
Build 348108,330,885 - 108,579,430NCBI
Celera8104,448,513 - 104,696,524 (-)NCBI
Cytogenetic Map8q23.1NCBI
HuRef8103,581,813 - 103,830,178 (-)NCBIHuRef
CHM1_18108,301,960 - 108,550,536 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on ANGPT1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733136
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-10-20
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.