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Gene: TJP2 (tight junction protein 2) Homo sapiens
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Symbol: TJP2
Name: tight junction protein 2
Description: Exhibits protein binding activity, bridging; protein domain specific binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including establishment of endothelial intestinal barrier; intestinal absorption; and positive regulation of maintenance of permeability of blood-brain barrier. Localizes to several cellular components, including the bicellular tight junction; cell-cell contact zone; and nucleus. Implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C9DUPq21.11; deafness, autosomal dominant 51; DFNA51; DUP9q21.11; Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; PFIC4; tight junction protein ZO 2; tight junction protein ZO-2; X104; ZO-2; ZO2; zona occludens 2; zona occludens protein 2; zonula occludens protein 2
Orthologs:
Mus musculus (house mouse) : Tjp2 (tight junction protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tjp2 (tight junction protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tjp2 (tight junction protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TJP2 (tight junction protein 2)
Canis lupus familiaris (dog) : TJP2 (tight junction protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tjp2 (tight junction protein 2)
Sus scrofa (pig) : TJP2 (tight junction protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38969,121,006 - 69,255,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37971,714,875 - 71,870,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36970,978,909 - 71,059,940 (+)NCBINCBI36hg18NCBI36
Build 34969,018,642 - 69,099,672NCBI
Celera942,332,221 - 42,460,614 (+)NCBI
Cytogenetic Map9q21.11NCBI
HuRef941,580,602 - 41,709,784 (+)NCBIHuRef
CHM1_1971,882,855 - 72,016,570 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TJP2
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733146
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.