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Gene: TJP2 (tight junction protein 2) Homo sapiens
Symbol: TJP2
Name: tight junction protein 2
Description: Exhibits protein binding activity, bridging; protein domain specific binding activity; and protein tyrosine kinase binding activity. Involved in several processes, including establishment of endothelial intestinal barrier; intestinal absorption; and positive regulation of maintenance of permeability of blood-brain barrier. Localizes to several cellular components, including the bicellular tight junction; cell-cell contact zone; and nucleus. Implicated in autosomal dominant nonsyndromic deafness 51; disease of metabolism; and progressive familial intrahepatic cholestasis 4.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C9DUPq21.11; deafness, autosomal dominant 51; DFNA51; DUP9q21.11; Friedreich ataxia region gene X104 (tight junction protein ZO-2); MGC26306; PFIC4; tight junction protein ZO 2; tight junction protein ZO-2; X104; ZO-2; ZO2; zona occludens 2; zona occludens protein 2; zonula occludens protein 2
Mus musculus (house mouse) : Tjp2 (tight junction protein 2)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tjp2 (tight junction protein 2)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tjp2 (tight junction protein 2)
Pan paniscus (bonobo/pygmy chimpanzee) : TJP2 (tight junction protein 2)
Canis lupus familiaris (dog) : TJP2 (tight junction protein 2)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tjp2 (tight junction protein 2)
Sus scrofa (pig) : TJP2 (tight junction protein 2)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38969,121,006 - 69,255,208 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37971,714,875 - 71,870,124 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36970,978,909 - 71,059,940 (+)NCBINCBI36hg18NCBI36
Build 34969,018,642 - 69,099,672NCBI
Celera942,332,221 - 42,460,614 (+)NCBI
Cytogenetic Map9q21.11NCBI
HuRef941,580,602 - 41,709,784 (+)NCBIHuRef
CHM1_1971,882,855 - 72,016,570 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TJP2
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733146
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.