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Gene: SNCA (synuclein alpha) Homo sapiens
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Symbol: SNCA
Name: synuclein alpha
Description: Exhibits several functions, including Hsp70 protein binding activity; cytoskeletal protein binding activity; and metal ion binding activity. Involved in several processes, including negative regulation of transport; positive regulation of transport; and regulation of protein metabolic process. Localizes to several cellular components, including the growth cone; inclusion body; and perinuclear region of cytoplasm. Colocalizes with the platelet alpha granule membrane. Implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Biomarker of several diseases, including Creutzfeldt-Jakob disease; Lewy body dementia; bipolar disorder; neurodegenerative disease (multiple); and vascular dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-synuclein; alpha-synuclein, isoform NACP140; I+/--synuclein; MGC110988; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; PARK1; PARK4; Parkinson disease (autosomal dominant, Lewy body) 4; PD1; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); truncated alpha synuclein
Orthologs:
Mus musculus (house mouse) : Snca (synuclein, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Snca (synuclein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Snca (synuclein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SNCA (synuclein alpha)
Canis lupus familiaris (dog) : SNCA (synuclein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Snca (synuclein alpha)
Sus scrofa (pig) : SNCA (synuclein alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38489,724,099 - 89,838,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37490,645,250 - 90,759,447 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36490,865,728 - 90,977,156 (-)NCBINCBI36hg18NCBI36
Build 34491,004,212 - 91,114,009NCBI
Celera487,942,196 - 88,056,576 (-)NCBI
Cytogenetic Map4q22.1NCBI
HuRef486,396,384 - 86,510,518 (-)NCBIHuRef
CHM1_1490,621,712 - 90,735,909 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
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Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SNCA
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733186
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.