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Gene: SNCA (synuclein alpha) Homo sapiens
Symbol: SNCA
Name: synuclein alpha
Description: Exhibits several functions, including Hsp70 protein binding activity; cytoskeletal protein binding activity; and metal ion binding activity. Involved in several processes, including negative regulation of transport; positive regulation of transport; and regulation of protein metabolic process. Localizes to several cellular components, including the growth cone; inclusion body; and perinuclear region of cytoplasm. Colocalizes with the platelet alpha granule membrane. Implicated in Alzheimer's disease; Lewy body dementia; Parkinson's disease; Parkinson's disease 1; and Parkinson's disease 4. Biomarker of several diseases, including Creutzfeldt-Jakob disease; Lewy body dementia; bipolar disorder; neurodegenerative disease (multiple); and vascular dementia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: alpha-synuclein; alpha-synuclein, isoform NACP140; I+/--synuclein; MGC110988; NACP; non A-beta component of AD amyloid; non-A beta component of AD amyloid; non-A4 component of amyloid; PARK1; PARK4; Parkinson disease (autosomal dominant, Lewy body) 4; PD1; synuclein alpha-140; synuclein, alpha; synuclein, alpha (non A4 component of amyloid precursor); truncated alpha synuclein
Mus musculus (house mouse) : Snca (synuclein, alpha)  MGI  Alliance
Rattus norvegicus (Norway rat) : Snca (synuclein alpha)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Snca (synuclein alpha)
Pan paniscus (bonobo/pygmy chimpanzee) : SNCA (synuclein alpha)
Canis lupus familiaris (dog) : SNCA (synuclein alpha)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Snca (synuclein alpha)
Sus scrofa (pig) : SNCA (synuclein alpha)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38489,724,099 - 89,838,324 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37490,645,250 - 90,759,447 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36490,865,728 - 90,977,156 (-)NCBINCBI36hg18NCBI36
Build 34491,004,212 - 91,114,009NCBI
Celera487,942,196 - 88,056,576 (-)NCBI
Cytogenetic Map4q22.1NCBI
HuRef486,396,384 - 86,510,518 (-)NCBIHuRef
CHM1_1490,621,712 - 90,735,909 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SNCA
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733186
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-05
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.