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Gene: LMNB1 (lamin B1) Homo sapiens
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Symbol: LMNB1
Name: lamin B1
CRRD ID: 733220
Description: Predicted to have double-stranded DNA binding activity. Predicted to be involved in interleukin-12-mediated signaling pathway. Localizes to nuclear membrane. Colocalizes with nuclear envelope. Implicated in adult-onset autosomal dominant demyelinating leukodystrophy.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: ADLD; lamin-B1; LMN; LMN2; LMNB; MGC111419
Orthologs:
Mus musculus (house mouse) : Lmnb1 (lamin B1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Lmnb1 (lamin B1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Lmnb1 (lamin B1)
Pan paniscus (bonobo/pygmy chimpanzee) : LMNB1 (lamin B1)
Canis lupus familiaris (dog) : LMNB1 (lamin B1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Lmnb1 (lamin B1)
Sus scrofa (pig) : LMNB1 (lamin B1)
Chlorocebus sabaeus (African green monkey) : LMNB1 (lamin B1)
Heterocephalus glaber (naked mole-rat) : Lmnb1 (lamin B1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl5126,776,623 - 126,837,020 (+)EnsemblGRCh38hg38GRCh38
GRCh385126,776,623 - 126,837,020 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375126,112,315 - 126,172,712 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365126,140,732 - 126,200,608 (+)NCBINCBI36hg18NCBI36
Build 345126,140,731 - 126,200,608NCBI
Celera5122,068,688 - 122,128,577 (+)NCBI
Cytogenetic Map5q23.2NCBI
HuRef5121,304,338 - 121,364,498 (+)NCBIHuRef
CHM1_15125,544,889 - 125,605,473 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on LMNB1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733220
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-10-06
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.