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Gene: TLE4 (TLE family member 4, transcriptional corepressor) Homo sapiens
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Symbol: TLE4
Name: TLE family member 4, transcriptional corepressor
Description: Predicted to have repressing transcription factor binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Localizes to the beta-catenin-TCF complex and nucleoplasm; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B lymphocyte gene 1; BCE-1; BCE1; E(spI); E(spl); enhancer of split groucho 4; ESG; ESG4; Grg-4; GRG4; groucho-related protein 4; transducin like enhancer of split 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, e(spl) homolog (drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(sp1); transducin-like enhancer protein 4
Orthologs:
Mus musculus (house mouse) : Tle4 (transducin-like enhancer of split 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tle4 (TLE family member 4, transcriptional corepressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tle4 (TLE family member 4, transcriptional corepressor)
Canis lupus familiaris (dog) : TLE4 (TLE family member 4, transcriptional corepressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tle4 (TLE family member 4, transcriptional corepressor)
Sus scrofa (pig) : TLE4 (TLE family member 4, transcriptional corepressor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38979,571,773 - 79,726,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37982,186,878 - 82,341,658 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36981,376,698 - 81,531,478 (+)NCBINCBI36hg18NCBI36
Build 34979,416,431 - 79,571,210NCBI
Celera952,764,232 - 52,919,003 (+)NCBI
Cytogenetic Map9q21.31NCBI
HuRef952,018,798 - 52,173,255 (+)NCBIHuRef
CHM1_1982,333,986 - 82,489,032 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TLE4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733230
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.