Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: TLE4 (TLE family member 4, transcriptional corepressor) Homo sapiens
Symbol: TLE4
Name: TLE family member 4, transcriptional corepressor
Description: Predicted to have repressing transcription factor binding activity and transcription corepressor activity. Predicted to be involved in negative regulation of canonical Wnt signaling pathway. Localizes to the beta-catenin-TCF complex and nucleoplasm; INTERACTS WITH (-)-epigallocatechin 3-gallate; 17beta-estradiol; aflatoxin B1.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: B lymphocyte gene 1; BCE-1; BCE1; E(spI); E(spl); enhancer of split groucho 4; ESG; ESG4; Grg-4; GRG4; groucho-related protein 4; transducin like enhancer of split 4; transducin-like enhancer of split 4 (E(sp1) homolog, Drosophila); transducin-like enhancer of split 4, e(spl) homolog (drosophila); transducin-like enhancer of split 4, homolog of Drosophila E(sp1); transducin-like enhancer protein 4
Mus musculus (house mouse) : Tle4 (transducin-like enhancer of split 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tle4 (TLE family member 4, transcriptional corepressor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tle4 (TLE family member 4, transcriptional corepressor)
Canis lupus familiaris (dog) : TLE4 (TLE family member 4, transcriptional corepressor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tle4 (TLE family member 4, transcriptional corepressor)
Sus scrofa (pig) : TLE4 (TLE family member 4, transcriptional corepressor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38979,571,773 - 79,726,882 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh37982,186,878 - 82,341,658 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 36981,376,698 - 81,531,478 (+)NCBINCBI36hg18NCBI36
Build 34979,416,431 - 79,571,210NCBI
Celera952,764,232 - 52,919,003 (+)NCBI
Cytogenetic Map9q21.31NCBI
HuRef952,018,798 - 52,173,255 (+)NCBIHuRef
CHM1_1982,333,986 - 82,489,032 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TLE4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733230
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.