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Gene: ITGB4 (integrin subunit beta 4) Homo sapiens
Symbol: ITGB4
Name: integrin subunit beta 4
Description: Exhibits G protein-coupled receptor binding activity. Contributes to insulin-like growth factor I binding activity and neuregulin binding activity. Involved in several processes, including hemidesmosome assembly; nail development; and skin morphogenesis. Localizes to several cellular components, including cell surface; hemidesmosome; and nucleus. Implicated in epidermolysis bullosa simplex localized type; junctional epidermolysis bullosa non-Herlitz type; and junctional epidermolysis bullosa with pyloric atresia.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD104; CD104 antigen; GP150; integrin beta 4; integrin beta-4; integrin beta-4 subunit; integrin, beta 4
Mus musculus (house mouse) : Itgb4 (integrin beta 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Itgb4 (integrin subunit beta 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Itgb4 (integrin subunit beta 4)
Pan paniscus (bonobo/pygmy chimpanzee) : ITGB4 (integrin subunit beta 4)
Canis lupus familiaris (dog) : ITGB4 (integrin subunit beta 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Itgb4 (integrin subunit beta 4)
Sus scrofa (pig) : ITGB4 (integrin subunit beta 4)
Chlorocebus sabaeus (African green monkey) : ITGB4 (integrin subunit beta 4)
Heterocephalus glaber (naked mole-rat) : Itgb4 (integrin subunit beta 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1775,721,328 - 75,757,818 (+)EnsemblGRCh38hg38GRCh38
GRCh381775,721,339 - 75,757,819 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371773,717,516 - 73,753,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361771,229,111 - 71,265,494 (+)NCBINCBI36hg18NCBI36
Build 341771,229,110 - 71,265,493NCBI
Celera1770,307,618 - 70,343,945 (+)NCBI
Cytogenetic Map17q25.1NCBI
HuRef1769,141,364 - 69,178,763 (+)NCBIHuRef
CHM1_11773,782,136 - 73,818,973 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on ITGB4
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733257
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-31
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.