Submit Data |  Help |  Video Tutorials |  News |  Publications |  FTP Download |  REST API |  Citing RGD |  Contact   
Gene: Cybb (cytochrome b-245, beta polypeptide) Mus musculus
Symbol: Cybb
Name: cytochrome b-245, beta polypeptide
Description: Exhibits superoxide-generating NADPH oxidase activity. Predicted to contribute to electron transfer activity. Involved in several processes, including hydrogen peroxide biosynthetic process; innate immune response; and superoxide metabolic process. Localizes to the NADPH oxidase complex and phagocytic vesicle. Predicted to colocalize with the perinuclear endoplasmic reticulum. Used to study chronic granulomatous disease and systemic lupus erythematosus. Human ortholog(s) of this gene implicated in X-linked chronic granulomatous disease; chronic granulomatous disease; and primary immunodeficiency disease. Is expressed in several structures, including alimentary system; brain; genitourinary system; immune system; and liver and biliary system. Orthologous to human CYBB (cytochrome b-245 beta chain).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: C88302; Cgd; CGD91-phox; Cyd; cytochrome b(558) subunit beta; cytochrome b-245 heavy chain; cytochrome b558 subunit beta; gp91-1; gp91-phox; gp91phox; heme-binding membrane glycoprotein gp91phox; NADPH oxidase 2; neutrophil cytochrome b 91 kDa polypeptide; Nox2; p22 phagocyte B-cytochrome
Homo sapiens (human) : CYBB (cytochrome b-245 beta chain)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Cybb (cytochrome b-245 beta chain)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : LOC102012042 (cytochrome b-245 heavy chain)
Pan paniscus (bonobo/pygmy chimpanzee) : LOC100982531 (cytochrome b-245 heavy chain)
Canis lupus familiaris (dog) : CYBB (cytochrome b-245 beta chain)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : LOC101966992 (cytochrome b-245 heavy chain)
Sus scrofa (pig) : GP91-PHOX (NADPH oxidase heavy chain subunit)
Chlorocebus sabaeus (green monkey) : CYBB (cytochrome b-245 heavy chain)
Heterocephalus glaber (naked mole-rat) : LOC101709509 (cytochrome b-245 heavy chain)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 EnsemblX9,435,252 - 9,487,771 (-)Ensembl
GRCm38X9,435,252 - 9,487,766 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv37X9,012,378 - 9,046,450 (-)NCBIGRCm37mm9NCBIm37
MGSCv36X8,593,665 - 8,626,226 (-)NCBImm8
CeleraX7,154,876 - 7,188,991 (-)NCBICelera
Cytogenetic MapX A1.1NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Cybb
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733265
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-12-18
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.