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Gene: TFRC (transferrin receptor) Homo sapiens
Symbol: TFRC
Name: transferrin receptor
CRRD ID: 733275
Description: Exhibits several functions, including double-stranded RNA binding activity; protein homodimerization activity; and transferrin receptor activity. Involved in several processes, including negative regulation of mitochondrial fusion; positive regulation of lymphocyte activation; and positive regulation of macromolecule metabolic process. Localizes to several cellular components, including HFE-transferrin receptor complex; clathrin-coated pit; and endosome. Implicated in breast carcinoma; immunodeficiency 46; multiple myeloma; and ovarian cancer. Biomarker of breast cancer; carcinoma (multiple); iron deficiency anemia; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor (p90, CD71); transferrin receptor protein 1; TRFR
Mus musculus (house mouse) : Tfrc (transferrin receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tfrc (transferrin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfrc (transferrin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : TFRC (transferrin receptor)
Canis lupus familiaris (dog) : TFRC (transferrin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfrc (transferrin receptor)
Sus scrofa (pig) : TFRC (transferrin receptor)
Chlorocebus sabaeus (African green monkey) : TFRC (transferrin receptor)
Heterocephalus glaber (naked mole-rat) : Tfrc (transferrin receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38.p13 Ensembl3196,027,183 - 196,082,096 (-)EnsemblGRCh38hg38GRCh38
GRCh383196,018,694 - 196,082,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,776,155 - 195,809,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,260,744 - 197,293,338 (-)NCBINCBI36hg18NCBI36
Build 343197,264,659 - 197,297,251NCBI
Celera3194,360,605 - 194,393,477 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,076,917 - 193,109,375 (-)NCBIHuRef
CHM1_13195,747,516 - 195,780,405 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on TFRC
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733275
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.