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Gene: TFRC (transferrin receptor) Homo sapiens
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Symbol: TFRC
Name: transferrin receptor
Description: Exhibits double-stranded RNA binding activity; protein homodimerization activity; and transferrin receptor activity. Involved in several processes, including positive regulation of lymphocyte activation; receptor internalization; and transferrin transport. Localizes to several cellular components, including the HFE-transferrin receptor complex; basolateral plasma membrane; and endosome. Implicated in breast carcinoma; multiple myeloma; ovarian cancer; and primary immunodeficiency disease. Biomarker of breast cancer; carcinoma (multiple); iron deficiency anemia; and prostate cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CD71; IMD46; p90; T9; TFR; TFR1; TR; transferrin receptor (p90, CD71); transferrin receptor protein 1; TRFR
Orthologs:
Mus musculus (house mouse) : Tfrc (transferrin receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tfrc (transferrin receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tfrc (transferrin receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : TFRC (transferrin receptor)
Canis lupus familiaris (dog) : TFRC (transferrin receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tfrc (transferrin receptor)
Sus scrofa (pig) : TFRC (transferrin receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh383196,018,694 - 196,082,123 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh373195,776,155 - 195,809,032 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 363197,260,744 - 197,293,338 (-)NCBINCBI36hg18NCBI36
Build 343197,264,659 - 197,297,251NCBI
Celera3194,360,605 - 194,393,477 (-)NCBI
Cytogenetic Map3q29NCBI
HuRef3193,076,917 - 193,109,375 (-)NCBIHuRef
CHM1_13195,747,516 - 195,780,405 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on TFRC
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733275
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.