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Gene: SLC22A4 (solute carrier family 22 member 4) Homo sapiens
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Symbol: SLC22A4
Name: solute carrier family 22 member 4
Description: Exhibits PDZ domain binding activity; carnitine transmembrane transporter activity; and cation:cation antiporter activity. Involved in carnitine transport. Localizes to the apical plasma membrane and mitochondrion. Implicated in rheumatoid arthritis.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deafness, autosomal recessive 60; DFNB60; ergothioneine transporter; ET transporter; integral membrane transport protein; MGC34546; MGC40524; OCTN1; organic cation transporter octn1; organic cation/carnitine transporter 1; solute carrier family 22 (organic cation/ergothioneine transporter), member 4; solute carrier family 22 (organic cation/zwitterion transporter), member 4
Orthologs:
Mus musculus (house mouse) : Slc22a4 (solute carrier family 22 (organic cation transporter), member 4)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc22a4 (solute carrier family 22 member 4)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc22a4 (solute carrier family 22 member 4)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC22A4 (solute carrier family 22 member 4)
Canis lupus familiaris (dog) : SLC22A4 (solute carrier family 22 member 4)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc22a4 (solute carrier family 22 member 4)
Sus scrofa (pig) : SLC22A4 (solute carrier family 22 member 4)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl5132,294,394 - 132,344,190 (+)Ensembl
GRCh385132,294,384 - 132,344,199 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh375131,630,145 - 131,679,899 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 365131,658,044 - 131,707,798 (+)NCBINCBI36hg18NCBI36
Build 345131,658,043 - 131,707,796NCBI
Celera5127,760,255 - 127,809,972 (+)NCBI
Cytogenetic Map5q31.1NCBI
HuRef5126,822,406 - 126,872,150 (+)NCBIHuRef
CHM1_15131,062,911 - 131,112,639 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC22A4
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733281
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-12-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.