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Gene: APAF1 (apoptotic peptidase activating factor 1) Homo sapiens
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Symbol: APAF1
Name: apoptotic peptidase activating factor 1
Description: This gene encodes a cytoplasmic protein that initiates apoptosis. This protein contains several copies of the WD-40 domain, a caspase recruitment domain (CARD), and an ATPase domain (NB-ARC). Upon binding cytochrome c and dATP, this protein forms an oligomeric apoptosome. The apoptosome binds and cleaves caspase 9 preproprotein, releasing its mature, activated form. Activated caspase 9 stimulates the subsequent caspase cascade that commits the cell to apoptosis. Alternative splicing results in several transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: APAF-1; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; CED4; DKFZp781B1145
Orthologs:
Mus musculus (house mouse) : Apaf1 (apoptotic peptidase activating factor 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Apaf1 (apoptotic peptidase activating factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apaf1 (apoptotic peptidase activating factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : APAF1 (apoptotic peptidase activating factor 1)
Canis lupus familiaris (dog) : APAF1 (apoptotic peptidase activating factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apaf1 (apoptotic peptidase activating factor 1)
Sus scrofa (pig) : APAF1 (apoptotic peptidase activating factor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh381298,645,141 - 98,735,433 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371299,039,078 - 99,129,211 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361297,563,209 - 97,653,342 (+)NCBINCBI36hg18NCBI36
Build 341297,541,545 - 97,631,678NCBI
Celera1298,703,974 - 98,794,106 (+)NCBI
Cytogenetic Map12q23.1NCBI
HuRef1296,100,029 - 96,190,306 (+)NCBIHuRef
CHM1_11299,004,024 - 99,094,151 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
 
More on APAF1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733293
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.