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Gene: Apaf1 (apoptotic peptidase activating factor 1) Mus musculus
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Symbol: Apaf1
Name: apoptotic peptidase activating factor 1
Description: ENCODES a protein that exhibits cysteine-type endopeptidase activator activity involved in apoptotic process; identical protein binding; heat shock protein binding (ortholog); INVOLVED IN activation of cysteine-type endopeptidase activity involved in apoptotic process; brain development; forebrain development; PARTICIPATES IN intrinsic apoptotic pathway; Alzheimer's disease pathway; amyotrophic lateral sclerosis pathway; ASSOCIATED WITH abnormal apoptosis; abnormal brain development; abnormal brain morphology; ASSOCIATED WITH Parkinsonian Disorders; Brain Injuries (ortholog); brain ischemia (ortholog); FOUND IN cytosol; nucleus; apoptosome (ortholog); INTERACTS WITH (S)-10-[(DIMETHYLAMINO)METHYL]-4-ETHYL-4,9-DIHYDROXY-1H-PYRANO[3',4':6,7]INOLIZINO[1,2-B]-QUINOLINE-3,14(4H,12H)-DIONE; 1,1-dichloroethene; 2,3,7,8-tetrachlorodibenzodioxine
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: 6230400I06Rik; Apaf-1; Apaf1l; apoptotic protease activating factor 1; apoptotic protease-activating factor 1; fog; forebrain overgrowth; KIAA0413; mKIAA0413
Orthologs:
Homo sapiens (human) : APAF1 (apoptotic peptidase activating factor 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Apaf1 (apoptotic peptidase activating factor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Apaf1 (apoptotic peptidase activating factor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : APAF1 (apoptotic peptidase activating factor 1)
Canis lupus familiaris (dog) : APAF1 (apoptotic peptidase activating factor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Apaf1 (apoptotic peptidase activating factor 1)
Sus scrofa (pig) : APAF1 (apoptotic peptidase activating factor 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm381090,989,311 - 91,082,743 (-)NCBIGRCm38GRCm38mm10GRCm38
MGSCv371090,452,056 - 90,545,488 (-)NCBIGRCm37mm9NCBIm37
MGSCv361090,420,401 - 90,512,501 (-)NCBImm8
Celera1092,983,615 - 93,080,742 (-)NCBICelera
Cytogenetic Map10 C2NCBI
cM Map1045.47NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Apaf1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733294
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2019-09-12
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.