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Gene: USP15 (ubiquitin specific peptidase 15) Homo sapiens
Symbol: USP15
Name: ubiquitin specific peptidase 15
Description: Exhibits several functions, including Lys48-specific deubiquitinase activity; cysteine-type peptidase activity; and ubiquitin modification-dependent histone binding activity. Involved in positive regulation of RIG-I signaling pathway; protein deubiquitination; and transmembrane receptor protein serine/threonine kinase signaling pathway. Localizes to cytosol and nucleus.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: deubiquitinating enzyme 15; FLJ55073; KIAA0529; MGC131982; MGC149838; MGC74854; ubiquitin carboxyl-terminal hydrolase 15; ubiquitin specific protease 15; ubiquitin thioesterase 15; ubiquitin thiolesterase 15; ubiquitin-specific-processing protease 15; UNPH-2; UNPH4
Mus musculus (house mouse) : Usp15 (ubiquitin specific peptidase 15)  MGI  Alliance
Rattus norvegicus (Norway rat) : Usp15 (ubiquitin specific peptidase 15)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Usp15 (ubiquitin specific peptidase 15)
Pan paniscus (bonobo/pygmy chimpanzee) : USP15 (ubiquitin specific peptidase 15)
Canis lupus familiaris (dog) : USP15 (ubiquitin specific peptidase 15)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Usp15 (ubiquitin specific peptidase 15)
Sus scrofa (pig) : USP15 (ubiquitin specific peptidase 15)
Chlorocebus sabaeus (African green monkey) : USP15 (ubiquitin specific peptidase 15)
Heterocephalus glaber (naked mole-rat) : Usp15 (ubiquitin specific peptidase 15)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl1262,260,338 - 62,417,431 (+)EnsemblGRCh38hg38GRCh38
GRCh381262,260,340 - 62,416,389 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371262,654,121 - 62,803,501 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361260,940,454 - 61,086,165 (+)NCBINCBI36hg18NCBI36
Build 341260,940,453 - 61,086,165NCBI
Celera1262,323,221 - 62,468,927 (+)NCBI
Cytogenetic Map12q14.1NCBI
HuRef1259,705,057 - 59,854,661 (+)NCBIHuRef
CHM1_11262,622,031 - 62,771,333 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
More on USP15
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733296
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.