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Gene: SH3BP5 (SH3 domain binding protein 5) Homo sapiens
Symbol: SH3BP5
Name: SH3 domain binding protein 5
Description: Exhibits Rab guanyl-nucleotide exchange factor activity and protein kinase inhibitor activity. Involved in intracellular signal transduction. Localizes to cytoplasmic vesicle membrane and nuclear body; INTERACTS WITH 17beta-estradiol; 3-isobutyl-1-methyl-7H-xanthine; 8-Br-cAMP.
Type: protein-coding
RefSeq Status: VALIDATED
Also known as: SAB; SH3 binding protein; SH3 domain-binding protein 5; SH3 domain-binding protein that preferentially associates with BTK; SH3-domain binding protein 5; SH3-domain binding protein 5 (BTK-associated); SH3BP-5
Mus musculus (house mouse) : Sh3bp5 (SH3-domain binding protein 5 (BTK-associated))  MGI  Alliance
Rattus norvegicus (Norway rat) : Sh3bp5 (SH3-domain binding protein 5)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sh3bp5 (SH3 domain binding protein 5)
Pan paniscus (bonobo/pygmy chimpanzee) : SH3BP5 (SH3 domain binding protein 5)
Canis lupus familiaris (dog) : SH3BP5 (SH3 domain binding protein 5)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sh3bp5 (SH3 domain binding protein 5)
Sus scrofa (pig) : SH3BP5 (SH3 domain binding protein 5)
Chlorocebus sabaeus (African green monkey) : SH3BP5 (SH3 domain binding protein 5)
Heterocephalus glaber (naked mole-rat) : Sh3bp5 (SH3 domain binding protein 5)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh38 Ensembl315,254,353 - 15,341,368 (-)EnsemblGRCh38hg38GRCh38
GRCh38315,254,353 - 15,341,380 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37315,295,860 - 15,382,901 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36315,271,361 - 15,357,905 (-)NCBINCBI36hg18NCBI36
Build 34315,271,367 - 15,348,892NCBI
Celera315,234,616 - 15,321,139 (-)NCBI
Cytogenetic Map3p25.1NCBI
HuRef315,231,318 - 15,318,336 (-)NCBIHuRef
CHM1_1315,246,746 - 15,333,790 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)

Gene-Chemical Interaction Annotations
Gene Ontology Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status


RNA-SEQ Expression


Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SH3BP5
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733305
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-03-24
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.