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Gene: SMO (smoothened, frizzled class receptor) Homo sapiens
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Symbol: SMO
Name: smoothened, frizzled class receptor
Description: Exhibits drug binding activity and patched binding activity. Involved in several processes, including detection of cell density by contact stimulus involved in contact inhibition; smooth muscle tissue development; and smoothened signaling pathway. Localizes to the intracellular membrane-bounded organelle and plasma membrane. Colocalizes with the Golgi apparatus and caveola. Implicated in basal cell carcinoma and pancreatic ductal carcinoma. Biomarker of basal cell carcinoma; nevoid basal cell carcinoma syndrome; and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CRJS; frizzled family member 11; FZD11; Gx; seven transmembrane helix receptor; SMOH; smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Orthologs:
Mus musculus (house mouse) : Smo (smoothened, frizzled class receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smo (smoothened, frizzled class receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smo (smoothened, frizzled class receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : SMO (smoothened, frizzled class receptor)
Canis lupus familiaris (dog) : SMO (smoothened, frizzled class receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smo (smoothened, frizzled class receptor)
Sus scrofa (pig) : SMO (smoothened, frizzled class receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh387129,188,633 - 129,213,548 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377128,828,713 - 128,853,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,615,949 - 128,640,622 (+)NCBINCBI36hg18NCBI36
Build 347128,422,663 - 128,447,334NCBI
Celera7123,625,432 - 123,650,109 (+)NCBI
Cytogenetic Map7q32.1NCBI
HuRef7123,189,938 - 123,214,626 (+)NCBIHuRef
CHM1_17128,762,307 - 128,786,971 (+)NCBICHM1_1
CRA_TCAGchr7v27128,212,668 - 128,237,345 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SMO
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733306
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.