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Gene: SMO (smoothened, frizzled class receptor) Homo sapiens
Symbol: SMO
Name: smoothened, frizzled class receptor
Description: Exhibits drug binding activity and patched binding activity. Involved in several processes, including detection of cell density by contact stimulus involved in contact inhibition; smooth muscle tissue development; and smoothened signaling pathway. Localizes to the intracellular membrane-bounded organelle and plasma membrane. Colocalizes with the Golgi apparatus and caveola. Implicated in basal cell carcinoma and pancreatic ductal carcinoma. Biomarker of basal cell carcinoma; nevoid basal cell carcinoma syndrome; and pancreatic cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: CRJS; frizzled family member 11; FZD11; Gx; seven transmembrane helix receptor; SMOH; smoothened homolog; smoothened, frizzled family receptor; smoothened, seven transmembrane spanning receptor
Mus musculus (house mouse) : Smo (smoothened, frizzled class receptor)  MGI  Alliance
Rattus norvegicus (Norway rat) : Smo (smoothened, frizzled class receptor)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Smo (smoothened, frizzled class receptor)
Pan paniscus (bonobo/pygmy chimpanzee) : SMO (smoothened, frizzled class receptor)
Canis lupus familiaris (dog) : SMO (smoothened, frizzled class receptor)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Smo (smoothened, frizzled class receptor)
Sus scrofa (pig) : SMO (smoothened, frizzled class receptor)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Human AssemblyChrPosition (strand)SourceGenome Browsers
GRCh387129,188,633 - 129,213,548 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh377128,828,713 - 128,853,386 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 367128,615,949 - 128,640,622 (+)NCBINCBI36hg18NCBI36
Build 347128,422,663 - 128,447,334NCBI
Celera7123,625,432 - 123,650,109 (+)NCBI
Cytogenetic Map7q32.1NCBI
HuRef7123,189,938 - 123,214,626 (+)NCBIHuRef
CHM1_17128,762,307 - 128,786,971 (+)NCBICHM1_1
CRA_TCAGchr7v27128,212,668 - 128,237,345 (+)NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
miRNA Target Status



Nucleotide Sequences
Protein Sequences
Clinical Variants

Additional Information

External Database Links
Nomenclature History
More on SMO
Alliance Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733306
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2019-11-26
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.