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Gene: Sphk1 (sphingosine kinase 1) Mus musculus
Symbol: Sphk1
Name: sphingosine kinase 1
Description: Exhibits D-erythro-sphingosine kinase activity; acetyltransferase activity; and sphinganine kinase activity. Involved in several processes, including negative regulation of ceramide biosynthetic process; regulation of vesicle-mediated transport; and sphingolipid mediated signaling pathway. Localizes to endocytic vesicle; nucleus; and presynapse. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SPHK1 (sphingosine kinase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110006G24Rik; acetyltransferase SPHK1; SK 1; SK1; SPK 1; Spk1
Homo sapiens (human) : SPHK1 (sphingosine kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sphk1 (sphingosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sphk1 (sphingosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPHK1 (sphingosine kinase 1)
Canis lupus familiaris (dog) : SPHK1 (sphingosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sphk1 (sphingosine kinase 1)
Sus scrofa (pig) : SPHK1 (sphingosine kinase 1)
Chlorocebus sabaeus (African green monkey) : SPHK1 (sphingosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Sphk1 (sphingosine kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
GRCm38 Ensembl11116,530,925 - 116,536,674 (+)EnsemblGRCm38mm10GRCm38
GRCm3811116,530,836 - 116,536,675 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711116,393,225 - 116,397,989 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611116,349,437 - 116,352,760 (+)NCBImm8
Celera11128,300,450 - 128,305,214 (+)NCBICelera
Cytogenetic Map11E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)

Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated


Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status



Nucleotide Sequences
Protein Sequences

Additional Information

External Database Links
More on Sphk1
Alliance Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733320
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE


RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.