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Gene: Sphk1 (sphingosine kinase 1) Mus musculus
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Symbol: Sphk1
Name: sphingosine kinase 1
Description: Exhibits D-erythro-sphingosine kinase activity; acetyltransferase activity; and sphinganine kinase activity. Involved in several processes, including negative regulation of ceramide biosynthetic process; regulation of vesicle-mediated transport; and sphingolipid mediated signaling pathway. Localizes to endocytic vesicle; nucleus; and presynapse. Human ortholog(s) of this gene implicated in type 2 diabetes mellitus. Is expressed in several structures, including genitourinary system; heart; liver; lung; and spleen. Orthologous to human SPHK1 (sphingosine kinase 1).
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1110006G24Rik; acetyltransferase SPHK1; SK 1; SK1; SPK 1; Spk1
Orthologs:
Homo sapiens (human) : SPHK1 (sphingosine kinase 1)  HGNC  Alliance
Rattus norvegicus (Norway rat) : Sphk1 (sphingosine kinase 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Sphk1 (sphingosine kinase 1)
Pan paniscus (bonobo/pygmy chimpanzee) : SPHK1 (sphingosine kinase 1)
Canis lupus familiaris (dog) : SPHK1 (sphingosine kinase 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Sphk1 (sphingosine kinase 1)
Sus scrofa (pig) : SPHK1 (sphingosine kinase 1)
Chlorocebus sabaeus (African green monkey) : SPHK1 (sphingosine kinase 1)
Heterocephalus glaber (naked mole-rat) : Sphk1 (sphingosine kinase 1)
more info ...
Latest Assembly: GRCm38 - Mouse Genome Assembly GRCm38
Position:
Mouse AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCm38 Ensembl11116,530,925 - 116,536,674 (+)EnsemblGRCm38mm10GRCm38
GRCm3811116,530,836 - 116,536,675 (+)NCBIGRCm38GRCm38mm10GRCm38
MGSCv3711116,393,225 - 116,397,989 (+)NCBIGRCm37mm9NCBIm37
MGSCv3611116,349,437 - 116,352,760 (+)NCBImm8
Celera11128,300,450 - 128,305,214 (+)NCBICelera
Cytogenetic Map11E2NCBI
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
QTLs in Region (GRCm38)
miRNA Target Status

Expression


Sequence

Nucleotide Sequences
Protein Sequences
Promoters

Additional Information

External Database Links
 
More on Sphk1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: mm9 mm10
MGI Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733320
Created: 2004-01-12
Species: Mus musculus
Last Modified: 2020-03-25
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.