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Gene: EIF2B1 (eukaryotic translation initiation factor 2B subunit alpha) Homo sapiens
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Symbol: EIF2B1
Name: eukaryotic translation initiation factor 2B subunit alpha
CRRD ID: 733321
Description: Exhibits identical protein binding activity. Contributes to guanyl-nucleotide exchange factor activity and translation initiation factor activity. Involved in T cell receptor signaling pathway; oligodendrocyte development; and translational initiation. Localizes to eukaryotic translation initiation factor 2B complex and plasma membrane. Implicated in leukoencephalopathy with vanishing white matter.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: EIF-2B; eIF-2B GDP-GTP exchange factor subunit alpha; EIF-2Balpha; EIF2B; EIF2BA; eukaryotic translation initiation factor 2B, subunit 1 alpha, 26kDa; MGC117409; MGC125868; MGC125869; translation initiation factor eif-2b alpha-subunit; translation initiation factor eIF-2B subunit alpha
Orthologs:
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl12123,620,406 - 123,633,766 (-)EnsemblGRCh38hg38GRCh38
GRCh3812123,620,406 - 123,633,686 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh3712124,105,570 - 124,118,323 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 3612122,671,523 - 122,684,200 (-)NCBINCBI36hg18NCBI36
Build 3412122,630,458 - 122,642,993NCBI
Celera12123,702,006 - 123,714,759 (-)NCBI
Cytogenetic Map12q24.31NCBI
HuRef12121,066,914 - 121,079,569 (-)NCBIHuRef
CHM1_112123,926,519 - 123,939,272 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
Promoters
Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on EIF2B1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733321
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.