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Gene: SLC12A3 (solute carrier family 12 member 3) Homo sapiens
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Symbol: SLC12A3
Name: solute carrier family 12 member 3
CRRD ID: 733325
Description: Predicted to have sodium:potassium:chloride symporter activity. Predicted to be involved in cell volume homeostasis; inorganic ion homeostasis; and inorganic ion transmembrane transport. Localizes to apical plasma membrane and extracellular exosome. Implicated in Gitelman syndrome and essential hypertension.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: FLJ96318; Na-Cl cotransporter; Na-Cl symporter; NaCl electroneutral thiazide-sensitive cotransporter; NCC; NCCT; solute carrier family 12 (sodium/chloride transporter), member 3; solute carrier family 12 (sodium/chloride transporters), member 3; solute carrier family 12, member 3; thiazide-sensitive Na-Cl cotransporter; thiazide-sensitive sodium-chloride cotransporter; TSC
Orthologs:
Mus musculus (house mouse) : Slc12a3 (solute carrier family 12, member 3)  MGI  Alliance
Rattus norvegicus (Norway rat) : Slc12a3 (solute carrier family 12 member 3)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Slc12a3 (solute carrier family 12 member 3)
Pan paniscus (bonobo/pygmy chimpanzee) : SLC12A3 (solute carrier family 12 member 3)
Canis lupus familiaris (dog) : SLC12A3 (solute carrier family 12 member 3)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Slc12a3 (solute carrier family 12 member 3)
Sus scrofa (pig) : SLC12A3 (solute carrier family 12 member 3)
Chlorocebus sabaeus (African green monkey) : SLC12A3 (solute carrier family 12 member 3)
Heterocephalus glaber (naked mole-rat) : Slc12a3 (solute carrier family 12 member 3)
more info ...
Related Pseudogenes: LOC100422510  
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38.p13 Ensembl1656,865,207 - 56,915,850 (+)EnsemblGRCh38hg38GRCh38
GRCh381656,865,207 - 56,915,850 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh371656,899,119 - 56,949,762 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 361655,456,643 - 55,504,850 (+)NCBINCBI36hg18NCBI36
Build 341655,456,642 - 55,504,850NCBI
Celera1641,398,377 - 41,450,052 (+)NCBI
Cytogenetic Map16q13NCBI
HuRef1642,768,662 - 42,819,218 (+)NCBIHuRef
CHM1_11658,307,135 - 58,357,791 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
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References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on SLC12A3
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733325
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-11-10
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.