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Gene: PLCD1 (phospholipase C delta 1) Homo sapiens
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Symbol: PLCD1
Name: phospholipase C delta 1
Description: Exhibits GTPase activating protein binding activity and phosphatidylinositol-4,5-bisphosphate binding activity. Predicted to be involved in inositol trisphosphate biosynthetic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. Localizes to the cytoplasm. Implicated in nonsyndromic congenital nail disorder 3. Biomarker of Alzheimer's disease.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: 1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase delta-1; 1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase delta-1; NDNC3; phosphoinositide phospholipase C-delta-1; Phospholipase C I 1; phospholipase C, delta 1; phospholipase C-delta-1; phospholipase C-III; PLC-delta-1; PLC-III
Orthologs:
Mus musculus (house mouse) : Plcd1 (phospholipase C, delta 1)  MGI  Alliance
Rattus norvegicus (Norway rat) : Plcd1 (phospholipase C, delta 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Plcd1 (phospholipase C delta 1)
Pan paniscus (bonobo/pygmy chimpanzee) : PLCD1 (phospholipase C delta 1)
Canis lupus familiaris (dog) : PLCD1 (phospholipase C delta 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Plcd1 (phospholipase C delta 1)
Sus scrofa (pig) : PLCD1 (phospholipase C delta 1)
Chlorocebus sabaeus (green monkey) : PLCD1 (phospholipase C delta 1)
Heterocephalus glaber (naked mole-rat) : Plcd1 (phospholipase C delta 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38 Ensembl338,007,496 - 38,029,762 (-)Ensembl
GRCh38338,007,496 - 38,029,642 (-)NCBIGRCh38GRCh38hg38GRCh38
GRCh37338,048,987 - 38,071,154 (-)NCBIGRCh37GRCh37hg19GRCh37
Build 36338,023,991 - 38,059,068 (-)NCBINCBI36hg18NCBI36
Build 34338,024,010 - 38,046,119NCBI
Celera337,983,370 - 38,005,535 (-)NCBI
Cytogenetic Map3p22.2NCBI
HuRef337,991,684 - 38,013,851 (-)NCBIHuRef
CHM1_1338,000,639 - 38,022,806 (-)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
Model


Disease Annotations
Gene-Chemical Interaction Annotations
Gene Ontology Annotations
Molecular Pathway Annotations
Phenotype Annotations
References - curated
References - uncurated

Genomics

Comparative Map Data
Position Markers
miRNA Target Status

Expression

RNA-SEQ Expression

Sequence

Nucleotide Sequences
Protein Sequences
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Clinical Variants

Additional Information

External Database Links
Nomenclature History
 
More on PLCD1
Alliance Gene
NCBI Gene
Ensembl Gene
JBrowse: hg19 hg38
HGNC Report
NCBI Genome Data Viewer

CRRD Object Information
CRRD ID: 733331
Created: 2004-01-12
Species: Homo sapiens
Last Modified: 2020-01-07
Status: ACTIVE



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RGD is funded by grant HL64541 from the National Heart, Lung, and Blood Institute on behalf of the NIH.