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Gene: TGFBR1 (transforming growth factor beta receptor 1) Homo sapiens
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Symbol: TGFBR1
Name: transforming growth factor beta receptor 1
Description: Exhibits several functions, including ATP binding activity; I-SMAD binding activity; and transforming growth factor beta binding activity. Contributes to growth factor binding activity. Involved in several processes, including positive regulation of signal transduction; protein phosphorylation; and response to cholesterol. Localizes to several cellular components, including the bicellular tight junction; cell surface; and membrane raft. Implicated in Ferguson-Smith tumor; Loeys-Dietz syndrome 1; Lynch syndrome; and urinary bladder cancer.
Type: protein-coding
RefSeq Status: REVIEWED
Also known as: AAT5; activin A receptor type II-like kinase, 53kD; activin A receptor type II-like kinase, 53kDa; activin A receptor type II-like protein kinase of 53kD; activin receptor-like kinase 5; ACVRLK4; ALK-5; ALK5; ESS1; LDS1; LDS1A; LDS2A; MSSE; multiple self-healing squamous epithelioma; mutant transforming growth factor beta receptor I; serine/threonine-protein kinase receptor R4; SKR4; tbetaR-I; TBR-i; TBRI; TGF-beta receptor type I; TGF-beta receptor type-1; TGF-beta type I receptor; TGFR-1; transforming growth factor beta receptor I; transforming growth factor, beta receptor 1; transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kD); transforming growth factor, beta receptor I (activin A receptor type II-like kinase, 53kDa); transforming growth factor-beta receptor type I
Orthologs:
Mus musculus (house mouse) : Tgfbr1 (transforming growth factor, beta receptor I)  MGI  Alliance
Rattus norvegicus (Norway rat) : Tgfbr1 (transforming growth factor, beta receptor 1)  Alliance
Chinchilla lanigera (long-tailed chinchilla) : Tgfbr1 (transforming growth factor beta receptor 1)
Pan paniscus (bonobo/pygmy chimpanzee) : TGFBR1 (transforming growth factor beta receptor 1)
Canis lupus familiaris (dog) : TGFBR1 (transforming growth factor beta receptor 1)
Ictidomys tridecemlineatus (thirteen-lined ground squirrel) : Tgfbr1 (transforming growth factor beta receptor 1)
Sus scrofa (pig) : TGFBR1 (transforming growth factor beta receptor 1)
more info ...
Allele / Splice: See ClinVar data
Latest Assembly: GRCh38 - Human Genome Assembly GRCh38
Position:
Human AssemblyChrPosition (strand)SourceGenome Browsers
JBrowseNCBIUCSCEnsembl
GRCh38999,104,038 - 99,154,192 (+)NCBIGRCh38GRCh38hg38GRCh38
GRCh379101,867,412 - 101,916,474 (+)NCBIGRCh37GRCh37hg19GRCh37
Build 369100,907,233 - 100,956,295 (+)NCBINCBI36hg18NCBI36
Build 34998,946,966 - 98,991,862NCBI
Celera972,381,280 - 72,430,335 (+)NCBI
Cytogenetic Map9q22.33NCBI
HuRef971,464,684 - 71,515,132 (+)NCBIHuRef
CHM1_19102,013,810 - 102,062,916 (+)NCBICHM1_1
JBrowse: View Region in Genome Browser (JBrowse)
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